Results 211 to 220 of about 2,011,905 (264)

Periostin‐CCL3 Feedforward Signaling Loop Promotes Cardiac Fibrosis and Cardiomyocyte Necroptosis in Arrhythmogenic Cardiomyopathy

Advanced Science, EarlyView.
POSTN‐CCL3 signaling forms a feed‐forward circuit between cardiomyocytes and cardiac myofibroblasts in arrhythmogenic cardiomyopathy. POSTN activates JNK/RIP3‐dependent necroptotic signaling and JNK/ETS2‐induced CCL3 expression in cardiomyocytes. In turn, CCL3‐CCR5 signaling in cardiac myofibroblasts activates NF‐κB/p65 and promotes POSTN expression ...
Tiantian Wu, Ruotong Li, Xiaoyue Zhang, Dandan Chen, Jianmeng Yang, Mengmeng Li, Yuhan Yin, Ya Wang, Yuqiu Tian, Haoling Yan, Dan Cui, Jiangping Song, Gaoliang Ouyang   +12 more
wiley   +1 more source

Mapping Embryonic Mouse Lung Development Using Enhanced Spatial Transcriptomics

Advanced Science, EarlyView.
The mammalian lung contains ∼50 cell types arranged along the airway epithelium. Here, deterministic barcoding sequencing (DBiT‐seq) is optimized to nearly double transcript recovery, enabling highly sensitive spatial mapping of the embryonic mouse lung.
Pengfei Zhang, Benjamin K. Law, Niles Huang, Katharine Goodwin, Celeste M. Nelson, Michelle M. Chan   +5 more
wiley   +1 more source

Decoding the Neural Circuit Underlying Context‐Cue Association in Retrieval of Morphine Reward Memory

Advanced Science, EarlyView.
Contextual cues recruit the glutamatergic vCA1–dmPFC pathway to retrieve morphine reward memory by reshaping cell‐type‐specific prefrontal microcircuit activity. Distinct regulation of PV+ and SST+ interneurons defines this hippocampal–prefrontal mechanism.
Zhifeng Shi, Guangying Li, Qian Yang, Rusun Liu, Linghan Gu, Mingmei Wang, John L. Waddington, Fuhai Ji, Xuechu Zhen   +8 more
wiley   +1 more source

Predictors of Early Mortality After Open Aorto-Iliac Reconstruction in Patients with Aortoiliac Occlusive Disease: An Observational Cohort Study. [PDF]

Medicina (Kaunas)
Imanbayev M, Dyussupov A, Tussupkanov B, Muratzhanov E, Mautbekova A, Kozubayeva D, Mukhametkhanov R, Gafurov R, Irgebayev N, Pavalkis D, Zhuravlev E, Sabitov Y.   +11 more
europepmc   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

RAF/MEK clamp inhibition with avutometinib and cetuximab in RAF1 S257L-mutated, anti-EGFR-refractory metastatic colorectal cancer in Gaucher's disease. [PDF]

Oncologist
Rose A, Rosenberg A, Grewal US, Brown TJ, Hornstein N.   +4 more
europepmc   +1 more source

Image-guided focused ultrasound for non-invasive modulation of superficial and deep tissues. [PDF]

STAR Protoc
Sangwan N, Chaggares NC, Torbatian Z, Anderson TA.   +3 more
europepmc   +1 more source

Understanding Anti-Diuretic Hormone Dynamics in Off pump Coronary Artery Bypass Grafting (OPCABG) Patients: A Case Series. [PDF]

Ann Card Anaesth
Dhanyee AS, Sivashanmugam T, Harini P, Kumar VRH, Ananthkumar S.   +4 more
europepmc   +1 more source

Stroke Risk After On-Pump Minimally Invasive Multivessel Coronary Artery Bypass Grafting With Right Axillary Artery Cannulation and Preoperative Computed Tomography Angiography. [PDF]

Interdiscip Cardiovasc Thorac Surg
Sellin C, Dörge H, Grossmann M, Durutya A, Rastan A, Tabesh N, Demianenko V.   +6 more
europepmc   +1 more source

Off-clamp versus on-clamp robot-assisted partial nephrectomy: A propensity-matched analysis

European Urology, 2023
Partial nephrectomy is the preferred treatment option for the management of small renal masses. On-clamp partial nephrectomy is associated with a risk of ischemia and a greater loss of postoperative renal function, while the off-clamp procedure decreases the duration of renal ischemia, leading to better renal function preservation.
Sharma, Gopal, Shah, Milap, Ahluwalia, Puneet, Dasgupta, Prokar, Challacombe, Benjamin J, Bhandari, Mahendra, Ahlawat, Rajesh, Rawal, Sudhir, Buffi, Nicolo M, Sivaraman, Ananthakrishanan, Porter, James R, Rogers, Craig, Mottrie, Alexandre, Abaza, Ronney, Rha, Khoon Ho, Moon, Daniel, Yuvaraja, Thyavihally B, Parekh, Dipen J, Capitanio, Umberto, Maes, Kris K, Porpiglia, Francesco, Turkeri, Levent, Gautam, Gagan   +22 more
core   +7 more sources