Results 171 to 180 of about 12,502,893 (300)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Reshaping the scissors: From directed evolution to AI-driven design for enhanced Cas performance. [PDF]

Biodes Res
Cheng X, Ruan W, Jin Z, Suo L, Ma Y, Jiang L, Zheng W, Li N, Hu W.   +8 more
europepmc   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Antidopaminergic Medications and Clinical Outcomes in Huntington Disease: Evidence From the PROOF-HD Placebo-Controlled Trial. [PDF]

Neurology
Anderson KE, Tan AM, Feigin A, Reilmann R, Rosser AE, Raymond LA, Kostyk SK, Saft C, Chen K, Hand R, Geva M, Hayden MR, PROOF-HD study investigators.   +12 more
europepmc   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Performative Architectures for Off-Grid Communities: Design Methodologies for Self-Sufficient Housing Solutions

Climate change and rising energy poverty reclaim the urgency for a new connection between design and energy. As a matter of fact, energy justice for vulnerable communities highlights the structural inequalities in the capitalist energy provision ...
Cascone, P., Laddaga, M.
core  

CRISPR-HAWK: haplotype- and variant-aware guide design toolkit for CRISPR-Cas. [PDF]

Bioinformatics
Kumbara A, Tognon M, Carone G, Fontanesi A, Bombieri N, Giugno R, Pinello L.   +6 more
europepmc   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Topology-optimized dielectric cavities for enhanced excitonic light emission from WSe₂. [PDF]

Light Sci Appl
Matthiessen O, Triplett B, Yesilyurt O, Cassara D, Pagadala K, Yang MM, Llacsahuanga Allcca AE, Ather H, Fruhling C, Solanki AB, Chen YP, Alaeian H, Kildishev AV, Shalaev VM, Capasso F, Boltasseva A, Mkhitaryan V.   +16 more
europepmc   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source