Results 51 to 60 of about 1,274,911 (296)

Parent‐to‐Child Information Disclosure in Pediatric Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Despite professional consensus regarding the importance of open communication with pediatric cancer patients about their disease, actual practice patterns of disclosure are understudied. Extant literature suggests a significant proportion of children are not told about their diagnosis/prognosis, which is purported to negatively ...
Rachel A. Kentor, Flora Hoodin, Michelle Byrd, Kristin A. Kullgren, Leah LaLonde, Lauren Benkoske, Patrick Smith, Dawn Carson, Karen MacDonald, Susumu Inoue, Brenda Kitchen, Kate Gowans, Gregory A. Yanik   +12 more
wiley   +1 more source

Radiotherapy Delivery in Deep Inspiration for Pediatric Patients—Final Results of the Phase II Feasibility Study TEDDI

Pediatric Blood &Cancer, EarlyView.
Abstract Introduction The TEDDI trial tested the feasibility and reproducibility of deep‐inspiration breath‐hold (DIBH) in pediatric patients referred for radiotherapy. This report presents final results, including patient‐reported outcomes (PRO) and dosimetric comparison of DIBH and free‐breathing (FB).
Daniella Elisabet Østergaard, Anni Young Lundgaard, Laura Ann Rechner, Danijela Dejanovic, Hanne Krogh Rose, Jolanta Hansen, Leila Vaalavirta, Miia Mokka, Marianne Aznar, Peder Skov Wehner, Lisa Lyngsie Hjalgrim, Maja Vestmø Maraldo   +11 more
wiley   +1 more source

Off-Design Performance Modeling of the Natural Gas-Fired Allam Cycle

Energies
This work focuses on modeling the performance of the natural gas-fired Allam cycle under off-design conditions. Key thermodynamic parameters, such as turbine inlet pressure (TIP), turbine inlet temperature (TIT), and turbine outlet temperature (TOT ...
Federico D’Ambrosio, Lorenzo Colleoni, Silvia Ravelli   +2 more
doaj   +1 more source

Whole-genome thermodynamic analysis reduces siRNA off-target effects. [PDF]

PLoS ONE, 2013
Small interfering RNAs (siRNAs) are important tools for knocking down targeted genes, and have been widely applied to biological and biomedical research.
Xi Chen, Peng Liu, Hui-Hsien Chou
doaj   +1 more source

Radial turbine performance measurement under extreme off-design conditions [PDF]

Energy, 2017
[EN] During automotive urban driving conditions and future homologation cycles, automotive radial turbines experience transient conditions, whereby the same operate at very high blade speed ratios and, thus, at very low power outputs. Under those conditions, the turbine power output might not be enough to feed the mechanical power needs of the ...
José Ramón Serrano, Andrés Tiseira, Luis Miguel García-Cuevas, Lukas Benjamin Inhestern, Hadi Tartoussi   +4 more
openaire   +3 more sources

Prolonged Corrected QT Interval as an Early Electrocardiographic Marker of Cyclophosphamide‐Induced Cardiotoxicity in Pediatric Hematology and Oncology Patients

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cyclophosphamide (CY) is associated with potentially fatal cardiotoxicity, yet no electrocardiographic indices have been established for early detection of CY‐induced cardiomyopathy. This study aimed to determine whether corrected QT interval (QTc) prolongation can predict early onset of CY‐related cardiac dysfunction in pediatric ...
Junpei Kawamura, Kentaro Ueno, Takuro Nishikawa, Yoshihiro Takahashi, Koji Nakae, Yasuhiro Okamoto   +5 more
wiley   +1 more source

Evaluation of a conserved glycoprotein precursor (GPC) derived, pan-Lassa fever T cell epitope-based vaccine candidate

The Microbe
Lassa fever (LF) is a viral zoonotic disease that can lead to fatal outcomes in some cases of human infection. Currently, no licensed vaccines are available to protect humans from this disease.
Rebecca Oziohu Omosimua, Srinivasan Prabhu, Baskar Venkidasamy, Naomi Adelola, Venkatramanan Varadharajan, Tolulope Uzoka, Rukayat Olajumoke Onilegbale, Chioma Ekwedigwe, Habeebah Fakayode, Zainab Ashimuyu-Abdulsalam, Akorede Daniel Aladeitan, Elizabeth Oladipo, Babatunde Salako, Adeola Olukosi   +13 more
doaj   +1 more source

CRISPR/Cas Systems in Genome Editing: Methodologies and Tools for sgRNA Design, Off‐Target Evaluation, and Strategies to Mitigate Off‐Target Effects

Advanced Science, 2020
Life sciences have been revolutionized by genome editing (GE) tools, including zinc finger nucleases, transcription activator‐Like effector nucleases, and CRISPR (clustered regulatory interspaced short palindromic repeats)/Cas (CRISPR‐associated) systems,
Hakim Manghwar, Bo Li, Xiao Ding, Amjad Hussain, Keith Lindsey, Xianlong Zhang, Shuangxia Jin   +6 more
doaj   +1 more source

Predicting Chronicity in Children and Adolescents With Newly Diagnosed Immune Thrombocytopenia at the Timepoint of Diagnosis Using Machine Learning‐Based Approaches

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives To identify predictors of chronic ITP (cITP) and to develop a model based on several machine learning (ML) methods to estimate the individual risk of chronicity at the timepoint of diagnosis. Methods We analyzed a longitudinal cohort of 944 children enrolled in the Intercontinental Cooperative immune thrombocytopenia (ITP) Study ...
Severin Kasser, Alice Bizeul, Meera Chitlur, Hugo Donato, Jelena Roganovic, Julia E. Vogt, Thomas Kühne   +6 more
wiley   +1 more source

How to Use an Optimization-Based Method Capable of Balancing Safety, Reliability, and Weight in an Aircraft Design Process

Nuclear Engineering and Technology, 2017
In order to help decision-makers in the early design phase to improve and make more cost-efficient system safety and reliability baselines of aircraft design concepts, a method (Multi-objective Optimization for Safety and Reliability Trade-off) that is ...
Cristina Johansson, Micael Derelöv, Johan Ölvander   +2 more
doaj   +1 more source