Results 1 to 10 of about 3,018,484 (379)

Off-Label Use vs Off-Label Marketing of Drugs

JACC: Basic to Translational Science, 2023
Once medical drugs and devices are approved for marketing by the FDA they can legally be used for purposes and in ways other than the ones for which they have been tested and approved. However, it is illegal for manufacturers to advertise or promote such unapproved uses of the drugs and devices.
Gail A. Van Norman
semanticscholar   +4 more sources

Antipsychotic off-label use in the 21st century: An enduring public health concern [PDF]

Dialogues in Clinical Neuroscience
Soon after the introduction of second-generation antipsychotics, antipsychotic off-label use (OLU) progressively became a common prescribing practice. This evolving practice should be regularly monitored considering the growing number of persons exposed ...
Hélène Verdoux
doaj   +2 more sources

Metabolic adverse effects of off-label use of second-generation antipsychotics in the adult population: a systematic review and meta-analysis [PDF]

Biological Psychiatry, 2021
Nicolette Stogios, Emily R. Smith, Sylvie Bowden, Veronica Tran, Roshanak Asgariroozbehani, William Brett McIntyre, Gary Remington, Dan Siskind, Sri Mahavir Agarwal, Margaret Hahn   +9 more
openalex   +2 more sources

Using Twitter data to understand public perceptions of approved versus off-label use for COVID-19-related medications [PDF]

J. Am. Medical Informatics Assoc., 2022
Objective Understanding public discourse on emergency use of unproven therapeutics is essential to monitor safe use and combat misinformation. We developed a natural language processing-based pipeline to understand public perceptions of and stances on ...
Y. Hua, Hang Jiang, Shixu Lin, Jie Yang, Joseph M. Plasek, D. Bates, Li Zhou   +6 more
semanticscholar   +1 more source

Off-Label Use of Tenecteplase for the Treatment of Acute Ischemic Stroke

JAMA Network Open, 2022
Key Points Question How does the use of tenecteplase compare with the use of alteplase in the clinical outcomes of patients with acute ischemic stroke (AIS) receiving intravenous thrombolysis?
A. Katsanos, K. Psychogios, G. Turc, S. Sacco, D. A. de Sousa, Gian Marco De Marchis, L. Palaiodimou, D. Filippou, N. Ahmed, A. Sarraj, B. Menon, G. Tsivgoulis   +11 more
semanticscholar   +1 more source

Off-label use of intravenous thrombolysis for acute ischemic stroke: a critical appraisal of randomized and real-world evidence

Therapeutic Advances in Neurological Disorders, 2021
Intravenous thrombolysis (IVT) represents the only systemic reperfusion therapy able to reverse neurological deficit in patients with acute ischemic stroke (AIS).
G. Tsivgoulis, O. Kargiotis, Gian Marco De Marchis, Martin Kohrmann, E. Sandset, T. Karapanayiotides, D. Sousa, A. Sarraj, A. Safouris, K. Psychogios, K. Vadikolias, D. Leys, P. Schellinger, A. Alexandrov   +13 more
semanticscholar   +1 more source

Management guideline for the off-label use of medicine in China (2021)

Expert Review of Clinical Pharmacology, 2022
Background Off-label drug use embodies a thorough clinical diagnosis and evaluation of treatment needs and should not be confused with unreasonable drug use, but it also faces potential risks with drug safety and legal issues. Research design and methods
W. Zuo, Yajia Sun, Rongji Liu, L. Du, N. Yang, Wenjuan Sun, Ping Wang, Xiaowan Tang, Yunlan Liu, Yuanyuan Ma, M. Meng, R. Lei, Xuelian Yan, Hua Peng, Qing Chang, Hui Pan, Bo Zhang, Yaolong Chen, Shuyang Zhang   +18 more
semanticscholar   +1 more source

Off-label antineoplastic drugs. An effectiveness and safety study [PDF]

Farmacia Hospitalaria, 2017
Objective: The use of antineoplastic medicines in special situations is common in clinical practice; it is strongly regulated and there is little information on its outcomes.
Cristina Arroyo Álvarez, Lourdes Rodríguez Pérez, María Eugenia Rodríguez Mateos, María José Martínez Bautista, Encarnación Benítez Rodríguez, José Manuel Baena- Cañada   +5 more
doaj   +1 more source

Off-label antibiotic use in a specialized children care hospital in Punjab, Pakistan: Findings and implications

Journal of Infection in Developing Countries, 2020
Introduction: Most of the antibiotics currently used in pediatrics are either unlicensed or being prescribed outside the specifications of product label (off-label prescribing).
Muhammad Hafeez, Zikria Saleem, Nasir Abbas Bukhari, Khalid Hussain, Rahat Shamim, Amjad Hussain, Nadeem Irfan Bukhari   +6 more
doaj   +1 more source

Off-Label Drug Use in Oncology

Креативная хирургия и онкология, 2022
The off-label use of medicines is a routine clinical practice of oncology, especially in malignant-tumour patients with no treatment alternatives left when registered-drug options have been exhausted or standard therapies reveal contraindications.
E. V. Karabina, D. D. Sakaeva, O. N. Lipatov   +2 more
doaj   +1 more source