Results 121 to 130 of about 3,028,209 (373)
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Automated detection of off-label drug use.
PLoS ONE, 2014 Off-label drug use, defined as use of a drug in a manner that deviates from its approved use defined by the drug's FDA label, is problematic because such uses have not been evaluated for safety and efficacy. Studies estimate that 21% of prescriptions are
Kenneth Jung +6 more
doaj +1 more source
Licensed medicines, off-label use or evidence based: which is most important? [PDF]
, 2016 Medicines are licensed for use in humans by regulatory authorities. The concept of licensing is that it helps ensure that medicines are safe, effective and of an adequate quality for regular use.1 Licensing was introduced due to concerns about safety not
Bua +8 more
core +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Child and Adolescent Psychiatry and Mental HealthBackground/Objectives Off-label psychopharmacologic medication use is widespread in child and adolescent psychiatry, but little is known about its associated factors.
Regina Taurines +26 more
doaj +1 more source
Off-label and unlicensed drug use in a Spanish Neonatal Intensive Care Unit
Farmacia Hospitalaria, 2017 Objetive: To describe off-label and unlicensed drugs in clinical practice in a Neonatal Intensive Care Unit (NICU).Method: The design of the study was a descriptive and retrospective three months research in a NICU of a Spanish University Hospital.
Belén Cabezuelo Escribano +6 more
doaj +1 more source
Treatment indications and potential off‐label use of antidepressants among older adults: A population‐based descriptive study in Denmark [PDF]
, 2022 Kazi Ishtiak‐Ahmed +3 more
openalex +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Simultaneous three-wavelength unwrapping using external digital holographic multiplexing module
, 2018 We present an external interferometric setup that is able to simultaneously acquire three wavelengths of the same sample instance without scanning or multiple exposures. This setup projects onto the monochrome digital camera three off-axis holograms with
Barnea, Itay +3 more
core +1 more source