Results 121 to 130 of about 3,018,484 (379)
Unlicensed and off-label drug use in children [PDF]
, 2002 Many commercially available drugs are only licensed for use in adults and for many drugs the available formulations are unsuitable for pediatric use.' This reality leads to use of drugs which are unlicensed or off -label for use in children.
Jong, G.W. (Geert) 't
core
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Licensed medicines, off-label use or evidence based: which is most important? [PDF]
, 2016 Medicines are licensed for use in humans by regulatory authorities. The concept of licensing is that it helps ensure that medicines are safe, effective and of an adequate quality for regular use.1 Licensing was introduced due to concerns about safety not
Bua +8 more
core +1 more source
Child and Adolescent Psychiatry and Mental HealthBackground/Objectives Off-label psychopharmacologic medication use is widespread in child and adolescent psychiatry, but little is known about its associated factors.
Regina Taurines +26 more
doaj +1 more source
Off-label and unlicensed drug use in a Spanish Neonatal Intensive Care Unit
Farmacia Hospitalaria, 2017 Objetive: To describe off-label and unlicensed drugs in clinical practice in a Neonatal Intensive Care Unit (NICU).Method: The design of the study was a descriptive and retrospective three months research in a NICU of a Spanish University Hospital.
Belén Cabezuelo Escribano +6 more
doaj +1 more source
Automated detection of off-label drug use.
PLoS ONE, 2014 Off-label drug use, defined as use of a drug in a manner that deviates from its approved use defined by the drug's FDA label, is problematic because such uses have not been evaluated for safety and efficacy. Studies estimate that 21% of prescriptions are
Kenneth Jung +6 more
doaj +1 more source
Off-label use of cardiovascular drugs as an indicator of therapeutic need in paediatrics [PDF]
, 2023 Silvia Miriam Cammarata, Giacomo Capone
openalex +1 more source
An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots
FEBS Letters, EarlyView.This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino +7 more
wiley +1 more source
Periprocedural Off-label Use of Rivaroxaban in Patient with Atrial Fibrillation and a Persistent Left Atrial Appendage Thrombus Despite Standard Anticoagulation Therapy: A Case Report [PDF]
, 2023 Archil Chukhrukidze, Zviad Kereselidze
openalex +1 more source
A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source