Results 131 to 140 of about 3,018,484 (379)

Tiludronate and clodronate do not affect bone structure or remodeling kinetics over a 60 day randomized trial [PDF]

, 2018
Background Tiludronate and clodronate are FDA-approved bisphosphonate drug therapies for navicular disease in horses. Although clinical studies have determined their ability to reduce lameness associated with skeletal disorders in horses, data regarding
Gillett, Ashley N., McNulty, Margaret A., Mitchell, Colin F., Richbourg, Heather A.   +3 more
core   +1 more source

Estimation of Percentage of Patients With Fibroblast Growth Factor Receptor Alterations Eligible for Off-label Use of Erdafitinib

JAMA Network Open, 2019
Key Points Question What is the potential upper bound of off-label use of erdafitinib in cancers with fibroblast growth factor receptor (FGFR) alterations?
Lélia Maria de Almeida Carvalho, Sandra de Oliveira Sapori Avelar, A. Haslam, J. Gill, V. Prasad   +4 more
semanticscholar   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Off-label use of upadacitinib in dermatology: a review

Journal of Dermatological Treatment
Objectives Upadacitinib, a selective JAK1 inhibitor, is approved for the treatment of atopic dermatitis but is increasingly used off-label in dermatology.
Hongtao Yu, Junkai Zhu, Xiaoli Ni, Kaiyu Yu, Zhen Mu   +4 more
doaj   +1 more source

Deutsche Krebsgesellschaft e.V.: Expertenkommission für Transparenz und Sicherheit im Off-Label-Use: Qualitativ hochwertige Versorgung von Patienten auf zuverlässiger Grundlage für Vertragsärzte [PDF]

, 2002
R. Kreienberg
openalex   +1 more source

Data_Sheet_1_Case Report: Off-Label Liraglutide Use in Children With Wolfram Syndrome Type 1: Extensive Characterization of Four Patients.docx

, 2021
Giulio Frontino (11833832), Tara Raouf (11833835), Daniele Canarutto (11833838), Eva Tirelli (11833841), Raffaella Di Tonno (11833844), Andrea Rigamonti (11600900), Maria Lucia Cascavilla (11833847), Cristina Baldoli (10662528), Roberta Scotti (11833850), Letizia Leocani (2839559), Su-Chun Huang (11833853), Franco Meschi (11833856), Graziano Barera (6579551), Vania Broccoli (54042), Greta Rossi (11833859), Silvia Torchio (611349), Raniero Chimienti (5792720), Riccardo Bonfanti (11510701), Lorenzo Piemonti (249842)   +18 more
openalex   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Simultaneous three-wavelength unwrapping using external digital holographic multiplexing module

, 2018
We present an external interferometric setup that is able to simultaneously acquire three wavelengths of the same sample instance without scanning or multiple exposures. This setup projects onto the monochrome digital camera three off-axis holograms with
Barnea, Itay, Eravuchira, Pinkie Jacob, Shaked, Natan T., Turko, Nir A.   +3 more
core   +1 more source

Drug utilisation and off-label use of medications in anaesthesia in surgical wards of a teaching hospital

Indian Journal of Anaesthesia, 2015
Background and Aims: When a drug is used in a way that is different from that described in regulatory body approved drug label, it is said to be ′off label use′. Perioperative phase is sensitive from the point of view of patient safety and off-label drug
Amol E Patil, Yashashri C Shetty, Snehalata V Gajbhiye, Sweta V Salgaonkar   +3 more
doaj   +1 more source