Results 161 to 170 of about 3,028,209 (373)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
Off-Label Use vs Off-Label Marketing
JACC: Basic to Translational Science, 2023 openaire +1 more source
Unlicensed and off-label drug use in a Swiss paediatric university hospital. [PDF]
, 2006 BACKGROUND: Many medicines used in newborns, infants, children and adolescents are not licensed ("unlicensed") or are prescribed outside the terms of the marketing authorization ("off-label").
Beck-Popovic, M. +8 more
core
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
USA: Off-Label-Use unter Schutz der Meinungsfreiheit – Quo vadis, Helvetia? [PDF]
, 2013 Christina Lindner +2 more
openalex +1 more source
Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy
European journal of internal medicine, 2020 Valentina Morena +27 more
semanticscholar +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Management of Tubal Pregnancy With Off-label Use of Letrozole in Monotherapy
, 2023 Iwona Gawron
openalex +1 more source
A dramatic case of Behçet disease successfully treated with infliximab [PDF]
, 2013 Behçet disease is a chronic relapsing systemic disease with possible life-threatening presentations. Management of this disease can be challenging and reports of the off-label use of anti-TNFα agents for the treatment of severe manifestations are ...
Alves, R. +3 more
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