Results 171 to 180 of about 3,018,484 (379)

Regulatory Actions on the Off-Label Use of Prescription Drugs: Ongoing Controversy and Contradiction in 2009 and 2010 [PDF]

, 2010
Kathleen A. Fairman, Frederic R. Curtiss
openalex   +1 more source

Off-Label Use vs Off-Label Marketing

JACC: Basic to Translational Science, 2023
openaire   +1 more source

Off-label use of medicines in neonates, infants, children, and adolescents: a joint policy statement by the European Academy of Paediatrics and the European society for Developmental Perinatal and Pediatric Pharmacology

European Journal of Pediatrics, 2020
L. Schrier, A. Hadjipanayis, T. Stiris, R. Ross-Russell, A. Valiulis, M. Turner, Wei Zhao, P. D. De Cock, S. D. de Wildt, K. Allegaert, J. N. van den Anker   +10 more
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Unlicensed and off-label drug use in a Swiss paediatric university hospital. [PDF]

, 2006
BACKGROUND: Many medicines used in newborns, infants, children and adolescents are not licensed ("unlicensed") or are prescribed outside the terms of the marketing authorization ("off-label").
Beck-Popovic, M., Cotting, J., Di Paolo, E.R., Fanconi, S., Frey, P., Gehri, M., Pannatier, A., Stoetter, H., Tolsa, J.F.   +8 more
core  

Off-label Use of an External Hand Fixator for Craniomaxillofacial Fractures – an Anatomical Feasibility Study [PDF]

, 2022
Florian Wichlas, Marco Necchi, Teresa Gruber, Valeska Hofmann, Susanne Deininger, Markus Sebastian Hubertus Deininger, Eva Steidle‐Kloc, Jan Pruszak, Christian Deininger   +8 more
openalex   +1 more source

Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy

European journal of internal medicine, 2020
Valentina Morena, L. Milazzo, L. Oreni, G. Bestetti, T. Fossali, C. Bassoli, A. Torre, M. Cossu, C. Minari, E. Ballone, Andrea Perotti, D. Mileto, F. Niero, S. Merli, A. Foschi, S. Vimercati, G. Rizzardini, S. Sollima, Lucia Bradanini, L. Galimberti, R. Colombo, V. Micheli, C. Negri, A. Ridolfo, L. Meroni, M. Galli, S. Antinori, M. Corbellino   +27 more
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Off label use of atrial septal occluder in huge arterio-venous malformation with giant aneurysm

, 2022
Raghda Ghonimy Elsheikh, Mohamed I. Hegab, Ayman Salam, Rania Zakaria   +3 more
openalex   +2 more sources