Results 231 to 240 of about 3,018,484 (379)

Off-Label Medication Use in Frontotemporal Dementia

, 2010
Bei Hu, Leslie Ross, John Neuhaus, David S. Knopman, Joel H. Kramer, Bradley F. Boeve, Richard J. Caselli, Neill R. Graff‐Radford, Mario F. Mendez, Bruce L. Miller, Adam L. Boxer   +10 more
openalex   +1 more source

Quetiapine Off-Label Use [PDF]

Value in Health, 2016
R Levin, I Cosmatos, G Dieck, J Reifsnyder   +3 more
openaire   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Off-label use of lung sealants: the need for evidence-based guidelines and adequate indications for use. [PDF]

J Thorac Dis
Hermans BP, Li WWL, van der Heide SM, Verhagen AFTM.   +3 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Excellent Results in the Off-Label Use of Denosumab in Pediatric Oncology: Monocentric Case Series Study. [PDF]

Case Rep Pediatr
Battaglia T, Nebiolo M, Conte M, Livellara V, Piatelli G, Damasio MB, Galleni B, Arkhangelskaya E, Manzitti C, Gaggero G, Garaventa A.   +10 more
europepmc   +1 more source

Physician-pharmacist agreement about off-label use of medications in private clinical settings in Baghdad, Iraq

, 2017
Saad Abdulrahman Hussain, Ashwaq Najemaldeen Abbas, Hasan A Alhadad, Ali Azeez Al‐Jumaili, Zainab Saad Abdulrahman   +4 more
openalex   +2 more sources

Erratum zu: Leitlinie zum „Off-Label-Use“ von Psychopharmaka im Kindes- und Jugendalter [PDF]

, 2013
C Veselý, Christine Vesely
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Off-label use of treprostinil in adult patients in clinical cases. [PDF]

World J Clin Cases
Mouratidou C, Pavlidis ET, Katsanos G, Kotoulas SC, Tsoulfas G, Mouloudi E, Taitzoglou IA, Galanis IN, Pavlidis TE.   +8 more
europepmc   +1 more source