Results 281 to 290 of about 3,018,484 (379)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

[Expert consensus on the management of off-label use of novel antineoplastic agents]. [PDF]

Zhejiang Da Xue Xue Bao Yi Xue Ban
Pharmaceutical Management Professional Committee of Zhejiang Provincial Hospital Association, Zhejiang Quality Control Center for Hospital Drug Affairs, Clinical Pharmaceutical Management Professional Committee of Shanghai Hospital Association, Hospital Pharmaceutical Management Professional Committee of Jiangsu Provincial Hospital Association, Pharmaceutical Management Professional Committee of Anhui Provincial Hospital Association.   +4 more
europepmc   +1 more source

INNV-16. Off-Label Use of Vorasidenib in IDH-Mutant Grade 3 and 4 Gliomas: A Single-Institution Experience [PDF]

Huda Alalami, Jethro Hu, Jeremy Rudnick, Rebecca Naor, J Wilson, Anne Cristine Guevarra   +5 more
openalex   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

The nationwide survey of Japanese public opinion about off-label use of anticancer drugs recommended by comprehensive genomic profiling. [PDF]

Int J Clin Oncol
Matsubara J, Mukai K, Muto M.
europepmc   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Off-label use of biologics and janus kinase (JAK) inhibitors for scarring alopecias: a narrative review. [PDF]

Arch Dermatol Res
Agarwal P, Ajuchi O, Lukowiak TM, Rao BK.   +3 more
europepmc   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Off-label Use of Dinutuximab Beta in Combination With Chemotherapy in Patients With Ewing Sarcoma: A Retrospective Single-center Case Series. [PDF]

J Pediatr Hematol Oncol
Spasov NJ, Dombrowski F, Lode H.
europepmc   +1 more source

Analysis Of Off-Label Medication Use For Oral Mucosal Diseases

Angel K.Y. Man
openalex   +1 more source