Results 51 to 60 of about 3,018,484 (379)

An Evaluation of the Effectiveness of Risk Minimization Measures for Tigecycline in the European Union [PDF]

, 2017
Background: Risk minimization measures (RMM) were implemented from February 2011 in the European Union to address risks of superinfection, off-label use and lack of efficacy associated with tigecycline.
Baillon Plot, Nathalie, Bassetti, Matteo, Eckmann, Christian, Frajzyngier, Vera, Hickman, Anne, Lundin, Rebecca, Montravers, Philippe, Quintana, Alvaro, Rottinghaus, Scott, Tucker, Hal, Wible, Michele   +10 more
core   +1 more source

Observational study on off-label use of tocilizumab in patients with severe COVID-19

European Journal of Hospital Pharmacy: Science and Practice, 2020
Background In December 2019 a novel coronavirus designated SARS-CoV-2 was identified, and the disease COVID-19 has caused many deaths. SARS-CoV-2 infection has been associated with the development of cytokine storm (including interleukin 6 (IL-6)), which
Laetitia Albertini, Mickael Soletchnik, A. Razurel, Johana Cohen, F. Bidégain, F. Fauvelle, Geoffroy Safrano, J. Piquet, C. Maurer, D. Goldgran‑Toledano   +9 more
semanticscholar   +1 more source

Off-label prescription of drugs at hospital [PDF]

Farmacia Hospitalaria, 2016
Objectives: To develop a procedure for management of off-label medications, and to analyze the treatments, indications, and hospital units which will request them more frequently, as well as which variables will have an impact on the authorization ...
Vicente Arocas Casañ, Jaime Mateo Carmona, Olga García Molina, Mº Ángeles Fernández de Palencia Espinosa, Mª José Blázquez Álvarez Espinosa, Mª Amelia de la Rubia Nieto, Jesús del Río García   +6 more
doaj   +1 more source

Potential Early Risk Biomarkers for Reduced Forced Expiratory Volume in Children Post‐Hematopoietic Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT We sought to identify potential early risk biomarkers for lung disease in children post‐allogeneic HCT. Patients with pulmonary function tests 3 months post‐transplant and plasma samples between days 7 and 14 post‐HCT were included. Six of 27 subjects enrolled had reduced forced expiratory volume 1 (FEV1) z scores.
Isabella S. Small, Pi Chun Cheng, April L. Rahrig, Courtney M. Rowan   +3 more
wiley   +1 more source

Automated Detection of Systematic Off-label Drug Use in Free Text of Electronic Medical Records. [PDF]

, 2013
Off-label use of a drug occurs when it is used in a manner that deviates from its FDA label. Studies estimate that 21% of prescriptions are off-label, with only 27% of those uses supported by evidence of safety and efficacy.
Jung, Kenneth, Lependu, Paea, Shah, Nigam   +2 more
core   +2 more sources

Available evidence and outcome of off-label use of rituximab in clinical practice [PDF]

, 2013
Purpose: To analyze the therapeutic indications for off-label use of rituximab, the available evidence for its use, the outcomes, and the cost. Methods: This was a retrospective analysis of patients treated with rituximab for off-label indications from ...
A. Agustí, A. Ferrer, A. López, A. Vallano, AS Bomback, B Coiffier, B Terrier, BD Cheson, BH Rovin, C Díaz-Lagares, C Melander, C. Alerany, DM Arnold, EM Allen Van, F Zaja, GJ Weiner, H Schulz, HC Kluin-Nelemans, I. Danés, J Narváez, J. A. Bosch, J. Cortés-Hernández, J. Martínez, JT Merrill, JZ Gillis, L Lightstone, M Pfreundschuh, M Ramos-Casals, M Ramos-Casals, M Trachana, MC Conde García, P Feugier, SJ Butterly, T Hampton, T Robak   +34 more
core   +2 more sources

The off-label use of anakinra in pediatric systemic autoinflammatory diseases

Therapeutic Advances in Musculoskeletal Disease, 2020
Interleukin 1 (IL-1), a central mediator of innate immunity, is considered a master cytokine of local and systemic inflammation. IL-1 has emerged as pivotal in the pathogenesis of autoinflammatory diseases (AIDs), and blockade of its pathway has become a
V. Maniscalco, S. Abu-Rumeileh, M. V. Mastrolia, E. Marrani, I. Maccora, I. Pagnini, G. Simonini   +6 more
semanticscholar   +1 more source

Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus, Floortje Strobbe, Annemarie A. Verrijn Stuart, Hanneke M. van Santen, Gerlof D. Valk, Sasja A. Schepers, Rachel S. van Leeuwaarde   +6 more
wiley   +1 more source

Model framework for off label use of medicines [PDF]

, 2016
Background The drug licensing regulatory system ensures that marketed drugs to be used, meet the high standards and requirements for quality, efficacy and safety.
Glavas Dodov, Marija, Koshi, Blerina, Nica, Vasilka, Simonovska Crcarevska, Maja, Slaveska-Raicki, Renata, Zisovska, Elizabeta   +5 more
core  

An Off-Label Use of Parental Rights? The Unanticipated Doctrinal Antidote for Professor Mnookin’s Diagnosis [PDF]

, 2014
In the intersection of technology, curriculum and intentions, a specific issue of interest is found in the gap between teachers’ intentions and implementations of curriculum.
Buss, Emily
core   +3 more sources