Results 71 to 80 of about 94,244 (228)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

De novo multi-objective generation framework for energetic materials with trading off energy and stability

npj Computational Materials
Energetic Materials (EMs) play important roles in military, civilian and aerospace fields. Energy and stability are the two most important but contradictory properties in practical application, thus leading to difficult challenges in developing new EMs ...
Jing Liu, Qiaolin Gou, Shangming Li, Yanzhi Guo, Yichen Hu, Yijing Liu, Xuemei Pu   +6 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Development and application of consensus in silico models for advancing high-throughput toxicological predictions

Frontiers in Pharmacology
Computational toxicology models have been successfully implemented to prioritize and screen chemicals. There are numerous in silico (quantitative) structure–activity relationship ([Q]SAR) models for the prediction of a range of human-relevant ...
Sean P. Collins, Brandon Mailloux, Sunil Kulkarni, Matthew Gagné, Alexandra S. Long, Tara S. Barton-Maclaren   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A Wearable Real-Time 2D/3D Eye-Gaze Interface to Realize Robot Assistance for Quadriplegics

IEEE Access
For people with severe sensory-based motor disorders or musculoskeletal disorders, robotic assistance offers a promising solution to improve their daily living standards.
Yongpeng Cao, Shouren Huang, Sune Lundo Sorensen, Yuji Yamakawa, Masatoshi Ishikawa   +4 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

'Stardust has always told facts, not gossip!' An interview with Nari Hira, founding editor of Stardust Magazine

The South Asianist, 2013
For 100 years, Indian cinema and its galaxy of stars have defined the drama on screen for generations of viewers and fans across the globe. For nearly half that time span, India's leading film magazine in English (and Hindi), Stardust, has been a much ...
Piyush Roy
doaj  

Basic Computational Algorithms for Representing an Aircraft Flight (Calculation of 3D Displacement and Displaying)

Axioms
This manuscript describes the computational process to calculate an airplane path and display it in a 2D and 3D coordinate system on a computer screen.
Adan Ramirez-Lopez
doaj   +1 more source