Results 61 to 70 of about 528 (267)

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

the Review and Critique of the Book “The Tragedy of Great Power Politics” [PDF]

پژوهش‌نامۀ انتقادی متون و برنامه‌های علوم انسانی, 2018
In the foregoing research, the critique and evaluation of John J. Mearsheimer's book "The Tragedy of Great Power Politics" is done in two levels: form criticism and content criticism.
Hasan Pourahmadi, Amir Abbasi Khoshkar
doaj  

CÂTEVA REPERE GEOPOLITICE ȘI DE SECURITATE PRIVIND STRATEGIA DE TRANSFORMARE A CHINEI ÎNTR-O SUPERPUTERE MARITIMĂ [PDF]

Revista de Știinţe Politice şi Relaţii Internaţionale, 2020
The sea route, known as China's Maritime Silk Road Initiative (MSRI), designed to link the South China Sea and the Mediterranean Sea, as part of the "Belt and Road Initiative" (BRI), proposes a long route that will pass through the Strait of Malacca, the
EUGEN LUNGU
doaj  

A Guide for Spatial Omics Technologies: Innovation, Evaluation, and Application

Advanced Science, EarlyView.
This review presents a strategy‐centric framework for spatial omics technologies, organizing methods by how spatial information is experimentally encoded. It compares key performance trade‐offs across sequencing‐ and imaging‐based approaches, examines computational and practical limitations, and highlights biomedical applications. The analysis provides
Xiaofeng Wu, Weize Xu, Da Lin, Leqiang Sun, Jinxia Dai, Gang Cao   +5 more
wiley   +1 more source

The ITGB2‐COPS3‐SOX2 Axis and SOX2 Liquid‐Liquid Phase Separation: Dual Mechanisms Governing Osteosarcoma Stemness

Advanced Science, EarlyView.
Osteosarcoma stemness is driven by the ITGB2‐COPS3‐SOX2 signaling axis. This study reveals that nuclear COPS3 stabilizes SOX2, which in turn undergoes liquid‐liquid phase separation to promote stemness. Based on this mechanism, a novel COPS3 inhibitor, Z‐5891, was developed, effectively suppressing tumor growth and stemness in vivo, offering a ...
Lei Guo, Zhiqing Zhao, Wei Wang, Jianfang Niu, Bing Wang, Yunfei Lin, Wei Guo, Taiqiang Yan   +7 more
wiley   +1 more source

Explaining the Ukraine war: a case for multi-theoretical approaches in international relations

Clío
This study examines the explanatory limits of realist and liberal theories in interpreting the Russian invasion of Ukraine and its repercussions on European security.
Lami Blendi
doaj   +1 more source

Cascade Therapy of Periodontitis via Sequential Release of Ribosome‐Targeting Antimicrobial Peptide and Irisin From a Multifunctional MOF‐Based System

Advanced Science, EarlyView.
This study presents a novel strategy for periodontitis treatment by co‐delivering a membrane‐ and ribosome‐targeting antimicrobial peptide GF and Irisin through a pH‐responsive metal‐organic framework. The system enables sequential release, providing rapid antibacterial action, anti‐inflammatory and antioxidative effects, as well as promoting bone ...
Yan Chen, Zheng Xu, Yunmo Xue, Shanshan Liu, Xiang Zhang, Jingyao Guo, Minhui Yao, Yue Liu, Xiaolin Lu, Jieshu Qian, Qian Ma   +10 more
wiley   +1 more source

Inherently Disordered Auxetic Metamaterials

Advanced Science, EarlyView.
Inherently disordered auxetic metamaterials based on random chiral Delaunay triangulations are designed and investigated using numerical simulations and experimental tests. These disordered frameworks exhibit orthotropic behavior and a large negative Poisson's ratio (ca.
Matteo Montanari, Reza Moghimimonfared, Andrea Spaggiari, Luke Mizzi   +3 more
wiley   +1 more source

Germany’s Strategic Contraction Following American Hegemony in the Context of Offensive Realism Theory

Güvenlik Stratejileri Dergisi
This study examines the position of the European continent within the international system, focusing specifically on Germany, from the years when the future of the global international system began to be debated following the Cold War up to the present ...
Tolga Öztürk
doaj   +1 more source

Este statul o persoana? Argumentele realismului stiintific explicate prin realismul ofensiv

Perspective Politice, 2020
Scopul acestui studiu este de a identifica argumentele realismului stiintific, formulate de catre Alexander Wendt, pe baza carora statul se defineste ca persoana sau ca actor in sistemul de state. Voi vorbi despre aceste argumente si motivele pentru care
Silviu-George COLONESCU
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