Results 121 to 130 of about 3,391,201 (348)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

The environmental performance of commercial buildings [PDF]

open access: yes
At the request of the Minister for Industry, Science and Resources, the Assistant Treasurer asked the Commission to undertake a research study examining the performance of commercial buildings and analyse any impediments to better performance of such ...
Productivity Commission
core  

President's Office File for Buildings and Grounds Committee, 1965-1972 [PDF]

open access: yes, 1965
Contains correspondence, reports, and other material related to the Board of Visitors' Buildings and Grounds Committee at the College of William and Mary.
College of William and Mary. Office of the President, Graves, Thomas Ashley, Jr.
core  

Real-Time Estimation and Monitoring of COVID-19 Aerosol Transmission Risk in Office Buildings. [PDF]

open access: yesSensors (Basel), 2023
Vanhaeverbeke J   +8 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Regulations and robust low-carbon buildings [PDF]

open access: yes, 2009
Building regulations and associated calculation methods have been rapidly evolving, driven in Europe by the European Union Energy Performance of Buildings Directive. As an example, the current UK regulations are explored in relation to buildings that are
Tuohy, Paul
core   +1 more source

Generic building modeling for non-residential buildings (especially office buildings) [PDF]

open access: yesE3S Web of Conferences
To promote sustainability in construction, planning must include dynamic analysis of renewable energies, as traditional methods fall short for this transition.
Weiß Dirk   +3 more
doaj   +1 more source

Indoor humidity levels and associations with reported symptoms in office buildings. [PDF]

open access: yesIndoor Air, 2022
Jones ER   +5 more
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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