Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane +19 more
wiley +1 more source
Bad Practices and Corrective Measures in the Inquisition District Tribunal of Llerena
Established in 1485, the Tribunal of the Holy Office of the Inquisition of Llerena was the subject of numerous inspection visits in the 16th and 17th centuries; these inspections determined the accountability of the members of the Court for improper ...
Isabel Martínez Navas
doaj +1 more source
Promoting health literacy about added sugars, with a focus on patients with limited English proficiency [PDF]
Excess consumption of added sugars has been linked to the development of obesity, diabetes, and cardiovascular disease. The sequelae of such health conditions accrue significant public health costs - both in terms of healthcare spending as well as ...
Kawasaki, Megan
core +1 more source
Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin +11 more
wiley +1 more source
Antimicrobial-Drug Prescription in Ambulatory Care Settings, United States, 1992–2000
During the 1990s, as antimicrobial resistance increased among pneumococci, many organizations promoted appropriate antimicrobial use to combat resistance.
Linda F. McCaig +2 more
doaj +1 more source
Trends in the utilisation of emergency departments in California, 2005-2015: a retrospective analysis. [PDF]
ObjectiveTo examine current trends in the characteristics of patients visiting California emergency departments (EDs) in order to better direct the allocation of acute care resources.DesignA retrospective study.SettingWe analysed ED utilisation trends ...
Guo, Joanna +4 more
core
Clinical Impact of NOTCH3 Variant Location After First Stroke in CADASIL
ABSTRACT Objective Despite its monogenic origin, Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy exhibits marked variability in clinical expression and severity. Variants in the NOTCH3 gene, within epidermal growth factor‐like repeat domains 1–6 or 7–34, are known to influence disease onset, but their impact ...
Léa Aguilhon +5 more
wiley +1 more source
Migraine treatment tweak could reduce office visits [PDF]
Add dexamethasone to the standard treatment of moderate to severe migraine headache; a single dose (8-24 mg) may prevent short-term recurrence, resulting in less need for medication and fewer repeat visits to the office or emergency department.
Ewigman, Bernard +2 more
core
Quality in home care for older people: factors to pay heed to [PDF]
23 home care providers were interviewed concerning what promotes or impedes quality aspects of service-giving, as defined by older customers – like service from familiar staff or flexible help.
Patmore, C
core +1 more source
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension phase).
Fabrizio De Benedetti +19 more
wiley +1 more source

