Results 91 to 100 of about 802,845 (313)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

The “Official Duties” Puzzle: Lower Courts’ Struggle With First Amendment Protection for Public Employees After Garcetti v. Ceballos [PDF]

, 2007
Since 1968, the threshold inquiry for determining whether the First Amendment protected public employees from retaliation for their speech was whether the employee spoke as a citizen on a matter of public concern.
Elzer, Christine
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Some Aspects of and Perspectives on the Public Prosecutor’s Objectivity according to ECtHR Case-Law

Bergen Journal of Criminal Law and Criminal Justice, 2015
The principle of objectivity includes several aspects of the prosecutor’s functions. This article highlights some aspects of and perspectives on the prosecutor’s role and raises some central questions regarding the prosecutor’s obligation to objectivity ...
Gert Johan Kjelby
doaj   +1 more source

General Provisions On Duties Of Company Officials In The Legislation Of Ukraine

Actual problems of improving of current legislation of Ukraine, 2020
The purpose of the article is to study the provisions of the current legislative acts of Ukraine, which regulate the legal status and duties of the company’s officials, compare the completeness and detail of the regulation of duties of officials for joint stock companies, limited liability companies and additional liability companies.
openaire   +2 more sources

The Federal Common Law Crime of Corruption [PDF]

, 2011
This contribution to the North Carolina Law Review’s 2010 symposium, Adaptation and Resiliency in Legal Systems, considers the compatibility between the common law nature of honest services fraud and the dynamic quality of public integrity offenses ...
Griffin, Lisa Kern
core   +2 more sources

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

The rights, duties and responsabilities of public officials [PDF]

, 2003
The concept of Good Administration (GA)is a conceptual and practical challenge for public administrations and their officials. This report seeks to shed some light on the way GA affects the rights, duties and responsabilities of public officials. In this connection and in order to open the debate, three subjects will be put forward for examination: the
openaire   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Legal and Moral Principles as Guidelines for Carrying Out Official Duties

Yuridika
Law and morals are related as an ideal value in the formation of law, because morals are considered universal values ​​that should ideally characterize every legal formation, with the hope that morality in the law can produce good behavior for legal subjects and objects.
Aries Saputro, Radian Salman
openaire   +2 more sources