Results 51 to 60 of about 802,845 (313)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Manuscrito, 2020 The item was in the news. A public official said that he would hire a male rather than a female driver, because following the growing influence of the #MeToo movement, hiring a man would be safer. That way nobody would accuse him of harassment.
YOTAM BENZIMAN
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The ability of the public employee to obey the illegal administrative decisions [PDF]
الرافدین للحقوق, 2019 The extent to which a public official obeys illegal administrate decisions is one of the important topics .presidential authority is no longer absolute in modern systems. A subordinate ،s obedience to a superior is not absolute; and the duty of obedience
Nawar Najeeb Tawfeeq +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Instruction au sein de la famille versus instruction au sein de l’école
Cahiers de la Recherche sur l'Education et les Savoirs, 2009 The compulsory attendance at school takes its origine in the principle of compulsory education stated in the Brazilian Law – obligation which is also present in the Federal Constitution. The National Council of Education has seen this principle contested
Carlos Roberto Jamil Cury
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Pravo, 2017 CRIMINAL offences committed in official capacity represent different kinds and forms of abuse of an official position or public authorities in the course of exercising official duties being performed by the authorized persons as holders of those ...
Bojana Golubović
doaj
Reporting Mental Health Symptoms: Breaking Down Barriers to Care with Virtual Human Interviewers
Frontiers in Robotics and AI, 2017 A common barrier to healthcare for psychiatric conditions is the stigma associated with these disorders. Perceived stigma prevents many from reporting their symptoms.
Gale M. Lucas +6 more
doaj +1 more source