Results 51 to 60 of about 801,907 (313)
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Crimes such as neglect of duty and misconduct are actions committed by public officer or civil servant ending up with public nuisance and also are actions defined as criminal acts in the law.
Gökçe GENÇAY, Kübra KARAL
doaj +1 more source
The item was in the news. A public official said that he would hire a male rather than a female driver, because following the growing influence of the #MeToo movement, hiring a man would be safer. That way nobody would accuse him of harassment.
YOTAM BENZIMAN
doaj +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The ability of the public employee to obey the illegal administrative decisions [PDF]
The extent to which a public official obeys illegal administrate decisions is one of the important topics .presidential authority is no longer absolute in modern systems. A subordinate ،s obedience to a superior is not absolute; and the duty of obedience
Nawar Najeeb Tawfeeq +2 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Instruction au sein de la famille versus instruction au sein de l’école
The compulsory attendance at school takes its origine in the principle of compulsory education stated in the Brazilian Law – obligation which is also present in the Federal Constitution. The National Council of Education has seen this principle contested
Carlos Roberto Jamil Cury
doaj +1 more source
VA Accountability Act of 2015 (H.R. 1994), as Reported to the House [PDF]
[Excerpt] This report describes the VA Accountability Act of 2015 (H.R. 1994) as reported to the House by the Committee on Veterans Affairs on July 23 2015 and compares it to current law where appropriate.
Carey, Maeve P +4 more
core +2 more sources
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source

