Results 71 to 80 of about 801,907 (313)

The “Official Duties” Puzzle: Lower Courts’ Struggle With First Amendment Protection for Public Employees After Garcetti v. Ceballos [PDF]

open access: yes, 2007
Since 1968, the threshold inquiry for determining whether the First Amendment protected public employees from retaliation for their speech was whether the employee spoke as a citizen on a matter of public concern.
Elzer, Christine
core   +2 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Increase in tobacco tax does not lead to increase in illicit cigarette consumption in Hong Kong: findings from a top-down approach against tobacco industry-funded results

open access: yesTobacco Induced Diseases, 2018
Background The tobacco industry consistently and persistently exaggerates that tobacco tax increase leads to increased illicit cigarette consumption (ICC).
Tai-Hing Lam   +4 more
doaj   +1 more source

Extending the duty of care to achieve justice for abused match officials

open access: yesThe International Sports Law Journal, 2022
AbstractThe welfare of participants in sport has historically been treated with lesser significance than other, largely commercial, considerations. In recent years, the wellbeing and treatment of athletes has come under the glare of the media and the public, due to a number of high-profile and deeply troubling claims of mistreatment and abuse whilst ...
openaire   +1 more source

Circular Number 2: Inspector General\u27s Office, Headquarters, U.S. Troops, Department of the Gulf, September 1, 1864 [PDF]

open access: yes
This 12 page official circular details all matter of drill, discipline and military duty as set generally in Circular Number 10, May 31, 1864. By command of Brigadier General George L. Andrews via Colonel S.M Quincy, Acting Assistant Inspector General.

core   +1 more source

The Federal Common Law Crime of Corruption [PDF]

open access: yes, 2011
This contribution to the North Carolina Law Review’s 2010 symposium, Adaptation and Resiliency in Legal Systems, considers the compatibility between the common law nature of honest services fraud and the dynamic quality of public integrity offenses ...
Griffin, Lisa Kern
core   +2 more sources

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Streamlining the Corruption Defense: A Proposed Framework for FCPA-ICSID Interaction [PDF]

open access: yes, 2014
Over the past decade, the number of Foreign Corrupt Practices Act (FCPA) enforcement actions has soared, as has the number of cases before the International Centre for Settlement of Investment Disputes (ICSID).
Losco, Michael A.
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

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