Results 61 to 70 of about 1,514,523 (353)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The State of Ukrainian after the Regaining of Independence by Ukraine in August 1991

open access: yesPółrocznik Językoznawczy Tertium, 2016
The article discusses changes in Ukrainian after Ukraine had regained independence. Prior to 1991, the Soviet authorities – apart from various prohibitions known from the time of Russian tsars – had created a system of interfering in internal laws of ...
Bożena Zinkiewicz-Tomanek
doaj   +1 more source

LEXEME OF KOREAN OFFICIAL LANGUAGE

open access: yesCURRENT RESEARCH JOURNAL OF PHILOLOGICAL SCIENCES, 2021
The article examines the vocabulary of Korean legislation, its general features, lexical units with common features used in legislation, methodological features, functions, lexical units that differ in their place in the formation of an official text, including methodically lexical units, neutral units of general speech and formal Special units in the
openaire   +2 more sources

The Economic Returns to a Second Official Language: English in Quebec and French in the Rest-of-Canada [PDF]

open access: yes
Canada is a country with two official languages, French and English. The need for both languages in Quebec and the Rest-of-Canada (ROC) generates a demand for bilingualism and investment in the acquisition of a second official language.
Christofides, Louis N.   +1 more
core  

Exploring the effectiveness of using big books in teaching primary English in Malaysian classrooms [PDF]

open access: yes, 2008
There are many benefits of using stories for language and literacy development particularly in the areas of vocabulary(Cameron, 2001; Elley, 1989; Penno, Wilkinson & Moore 2002;Hargrave & Senechal, 2000) and reading comprehension.
Pinter, Annamaria, Yaacob, Aizan
core  

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Economic Returns to the Knowledge and Use of a Second Official Language: English in Quebec and French in the Rest-of-Canada [PDF]

open access: yes
In a country with two official languages, such as Canada, the demand for bilingualism may lead individuals born with one mother tongue to acquire the second official language.
Louis N. Christofides, Robert Swidinsky
core  

Justice (Vol. 25, Iss. 18) [PDF]

open access: yes, 1943
Justice was the official publication of the International Ladies’ Garment Workers’ Union ILGWU from 1919 to 1995. Editions of Justice were published in English, Italian, Spanish, and Yiddish.
International Ladies Garment Workers Union (ILGWU)
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

open access: yesMolecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson   +2 more
wiley   +1 more source

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