Results 61 to 70 of about 191,060 (306)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Language Policy in the U.S.: Debating Official Language [PDF]
, 2016 U. S. does not have an official language even though the country is home to the highest number of English speakers in the world and English is the primary language spoken there.
Mertová, Viktorie
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Official language use in Berehove in 1919-1920
Acta Academiae Beregsasiensis, PhilologicaThe political map of East-Central Europe changed after the First World War. But this transformation also affected many different aspects of everyday life. In particular, the years of transition from the collapsing empires to the new republics offer rich
Imre Szakál, Gabriella Mádi
doaj +1 more source
‘A Decision of the Zargo’ as an 18th-Century Linguistic Source
Монголоведение, 2018 The paper introduces into scientific discourse a document contained in Kalmykia’s National Archive which is a decision of the Zargo Court, a consultative organ affiliated to the executive office of the Kalmyk Khanate and endowed with ...
D. Gedeeva
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
The Economic Returns to the Knowledge and Use of a Second Official Language: English in Quebec and French in the Rest-of-Canada [PDF]
In a country with two official languages, such as Canada, the demand for bilingualism may lead individuals born with one mother tongue to acquire the second official language.
Louis N. Christofides, Robert Swidinsky
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Journal of Ethnology and Folkloristics, 2013 This study explores the legal and institutional position of Finno-Ugric languages according to the language laws of the national republics in post-Soviet Russia.
Konstantin Zamyatin
doaj
Important issues related to the official language of India
Әл-Фараби Атындағы Қазақ Ұлттық Университеті хабаршы шығыстану сериясы, 2020 Popularization and implementation of the state language cannot be successful without a clear and scientific analysis of the general language situation. Sociological and sociolinguistic monitoring provides adjustments in language policy that reflect the ...
Ocпaн Н.A., Кoкeeвa Д.М.
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Economic Returns to a Second Official Language: English in Quebec and French in the Rest-of-Canada [PDF]
Canada is a country with two official languages, French and English. The need for both languages in Quebec and the Rest-of-Canada (ROC) generates a demand for bilingualism and investment in the acquisition of a second official language.
Swidinsky, Robert +1 more
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