Results 61 to 70 of about 4,652 (272)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Perceptions of the EU and Democratic Values [PDF]

, 2013
The European Union (EU) with its 27 Member States and 3 official candidate states is an important example of a region with a culturally diverse population.
Aktan, Ebru, Eryaman, Mustafa Yunus, Genc, Salih Zeki   +2 more
core   +1 more source

France and The European Charter for Regional or Minority Languages: Dilemma without Solution

Vestnik MGIMO-Universiteta, 2015
There are more than seven thousand of unique languages nowadays, that reflect the uniqueness of the living conditions, the worldview and cultural traditions of different peoples.
Ella V. Ermakova
doaj   +5 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Contested Languages and Perception of Multilingualism: A Sociolinguistic Study of Poland and Italy

Cognitive Studies | Études cognitives
Most European states, including Poland and Italy, have diverse linguistic composition, yet only a fraction of their language varieties receive official recognition and support.
Nicole Dołowy, Claudia Soria
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Ever Closer Union or Babylonian Discord? [PDF]

Extensive multilingualism is one of the most important and fundamental principles of the European Union. However, a large number of official languages (currently 23) hinders communication and imposes substantial financial and legal costs.
Jan Fidrmuc, Schlomo Weber, Victor Ginsburgh   +2 more
core  

Perspectives of South-Slavic languages teaching in the context of the current language policy of the European Union

Opera slavica, 2014
The process of European integration, which is in the region of the former Yugoslavia at the beginning, is one of the greatest attributes of contemporary social changes.
Miroslav Kouba
doaj  

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

The EU language policy and interpreting/translation practices: the case of Croatia's application for EU membership

, 2005
The EU is considered by most to have exemplary language and interpreting/translating (I/T) policies: EU parliamentarians may use their own language when speaking in parliament and the 20 official languages of all 25 member states have equal status in ...
Hlavac, Jim
core