Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Economic Statistics and U.S. Agricultural Policy [PDF]
Economic statistics can be used to inform policy as it is being designed, avoid policy design mistakes, or implement government programs once they are established into law. Oftentimes, statistics are used for all three purposes.
Ahearn, Mary Clare +2 more
core +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
A Dynamic Factor Model Approach to Incorporate Big Data in State Space Models for Official Statistics [PDF]
, 2020 Caterina Schiavoni +3 more
openalex +1 more source
Official population statistics and the Human Mortality Database estimates of populations aged 80+ in Germany and nine other European countries [PDF]
A systematic comparison of the Human Mortality Database and official estimates of populations aged 80+ is presented. We consider statistical series for East and West Germany and also for Denmark, England and Wales, France, Finland, Hungary, the ...
Dmitri A. Jdanov +2 more
core
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Toward global comparability of sexual orientation data in official statistics: a conceptual framework of sexual orientation for health data collection in New Zealand's official statistics system. [PDF]
J Environ Public Health, 2013 Pega F +4 more
europepmc +1 more source
Official statistics release : early years and childcare inspections and outcomes : 1 September 2008 to 31 March 2012 : provisional [PDF]
, 2012 Sue Gregory, Steve Ball
openalex