Results 161 to 170 of about 1,455,130 (355)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Harnessing Official Statistics [PDF]

open access: yesInternational Journal of Health Care Quality Assurance, 2001
openaire   +2 more sources

Combining serological assays and official statistics to describe the trajectory of the COVID-19 pandemic: results from the EPICOVID19-RS study in Rio Grande do Sul (Southern Brazil)

open access: yes, 2021
Hartwig FP   +10 more
europepmc   +1 more source

The Measurement of Output and Productivity in the Health Care Sector in Canada: An Overview [PDF]

open access: yes
To achieve efficient allocation of resources in the health care sector, accurate measures of health care output and productivity are essential. According to official estimates of productivity produced by Statistics Canada, labour productivity in the ...
Andrew Sharpe   +2 more
core  

Effect of chemotherapy on passenger mutations in metastatic colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui   +6 more
wiley   +1 more source

The Evolution of Official Statistics in a Changing World

open access: yesHarvard Data Science Review, 2021
Wesley Yung
doaj   +1 more source

FIGARO-E3: a high-resolution extended multi-regional input-output database consistent with official statistics. [PDF]

open access: yesSci Data
Cazcarro I   +6 more
europepmc   +1 more source

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