Results 111 to 120 of about 16,974 (127)

Ofloxacin and Pulmonary Tuberculosis

Chest, 1994
We read with great interest the article by Kohno et at published in the December, 1992, issue of Chest concerning the comparison of ofloxacin and ethambutol in the treatment of pulmonary beos’ We wish to supplement and reiterate on several issues concerning the potential role of ofloxacin for the treatment of pulmonary tuberculosis.
Wing Wai Yew, Poon Chuen Wong, Chi Hung Chau, Joseph Lee   +3 more
openaire   +2 more sources

The effect of food on the pharmacokinetics of ofloxacin

Current Medical Research and Opinion, 1986
After oral administration of a single dose of ofloxacin (300 mg), with and without a standard breakfast, to 12 healthy male volunteers in an open, randomized crossover study, concentrations of the unchanged drug were estimated at various times in serum and urine, over 28 hours and 48 hours, respectively. Each dose was followed by a wash-out period of 1
A Korn, V Malerczyk, M Verho, E. E. Dagrosa   +3 more
openaire   +2 more sources

The comparative in-vitro activity of ofloxacin

Journal of Antimicrobial Chemotherapy, 1988
The antibacterial activity of ofloxacin, a new fluoroquinolone, was evaluated against a wide range of clinical bacterial isolates and compared with that of nalidixic acid, norfloxacin, enoxacin, pefloxacin and ciprofloxacin by determination of minimum inhibitory concentrations (MICs).
M J Robbins, R. N. Grüneberg, David Felmingham, Robert Wall, G. L. Ridgway, K. Perry, O'Hare   +6 more
openaire   +3 more sources

The penetration of ofloxacin into bronchial secretions

Journal of Antimicrobial Chemotherapy, 1988
Penetration of ofloxacin into bronchial secretions following a single 400 mg oral dose was studied in 52 patients. Bronchial secretions were aspirated at bronchoscopy between one and 24 h after dosing and blood was collected at the same time. Mean bronchial secretion concentrations between 2 and 2.6 mg/l were measured in 36 patients between 1 and 6 h ...
Anne Turner, Jane Symonds, Michael F. Bone, Arshad Javaid   +3 more
openaire   +3 more sources

Treatment of typhoid fever with ofloxacin

Journal of Antimicrobial Chemotherapy, 1989
Ofloxacin, 300 mg 12-hourly, was given orally to 64 patients with typhoid fever, all with positive blood cultures. Almost 80% of the isolates were resistant to chloramphenicol, ampicillin and co-trimoxazole, but sensitive to ofloxacin and norfloxacin. Fever subsided within five days in most patients (mean 3.2 +/- 1.1), rates of clinical effectiveness ...
Fu. Wang, Tze-ying Tai, Mei-fang Zhang, Xian-jin Gu   +3 more
openaire   +3 more sources

Efficacy of ofloxacin in uncomplicated gonorrhoea

Infection, 1986
A randomised double blind trial comparing single oral dose therapy with 200 mg and 400 mg of ofloxacin, respectively was conducted at the Bangrak Hospital, Bangkok during the period December 6, 1985 to January 24, 1986. We treated 234 male patients diagnosed as having uncomplicated gonococcal urethritis with ofloxacin.
C. Ariyarit, A. Buatiang, K. Panikabutra, Wongba C, Chitwarakorn A   +4 more
openaire   +3 more sources

Ofloxacin

2010
Ofloxacin is a fluoroquinolone antibiotic first synthesized at Daiichi Pharmaceutical Company, Japan, in 1980. It has the chemical formula 9-fluoro-3-methyl-10-(4-methyl-1- piperazinyl)-7-oxo-2,3-dihydro-7H-pyrido-(1,2,3-de)1,4- benzoxazine-6-carboxylic acid (Sato et al., 1982; Kumazawa and Yagisawa, 2002).
openaire   +1 more source

Effect of Gender on the Pharmacokinetics of Ofloxacin

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 1999
Study Objectives. To assess the influence of gender on the pharmacokinetics of ofloxacin.Design. Open‐label study.Setting. Academic medical center.Patients. Five healthy men and seven healthy women volunteers.Interventions. Subjects received a single oral dose of ofloxacin 400 mg, and serial blood samples were collected for 24 hours.
Kevin M. Sowinski, William R. Clark, Steven R. Abel, Bruce A. Mueller   +3 more
openaire   +3 more sources

Review of Preclinical Studies with Ofloxacin

Clinical Infectious Diseases, 1992
Most Enterobacteriaceae, enteropathogens, and fastidious gram-negative bacteria are highly susceptible to ofloxacin, a new tricyclic fluoroquinolone. Aerobic gram-negative bacilli and gram-positive bacteria are generally not as susceptible to ofloxacin.
openaire   +3 more sources

Pharmacokinetics of ofloxacin in broiler chicken

Journal of Veterinary Pharmacology and Therapeutics, 2006
Pharmacokinetics of ofloxacin, a fluoroquinolone antimicrobial agent, was determined in broiler chickens after intravenous or oral administration of a single dose (10 mg/kg). Ofloxacin concentrations in plasma were determined using a high‐performance liquid chromatography assay. Plasma concentration profiles were analyzed by the noncompartmental method.
L. N. Mathuram, L. Kalaiselvi, S. Ramesh, P Sriram, D Sriranjani   +4 more
openaire   +3 more sources