Results 211 to 220 of about 38,750 (269)
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Annals of Pharmacotherapy, 1997
OBJECTIVE: To describe a possible case of ofloxacin-induced generalized tonic—clonic seizure. Although the etiology is unknown, ofloxacin most likely precipitated this patient's seizure threshold because of sepsis or secondary to drug accumulation due to the patient's compromised renal function.
Jeremy K Hon +2 more
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OBJECTIVE: To describe a possible case of ofloxacin-induced generalized tonic—clonic seizure. Although the etiology is unknown, ofloxacin most likely precipitated this patient's seizure threshold because of sepsis or secondary to drug accumulation due to the patient's compromised renal function.
Jeremy K Hon +2 more
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Ofloxacin, a Bactericidal Antibacterial
Chemotherapy, 1991Ofloxacin, like other 4-quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial DNA synthesis, rather than cell wall or protein synthesis. The 4-quinolones are also unusual because even for serious infections they can be given orally.
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Resistance studies with ofloxacin
Journal of Antimicrobial Chemotherapy, 1988The selection of ofloxacin-resistant mutants from susceptible wild-type bacterial populations was investigated by three methods. Resistant mutants selected from populations of Escherichia coli (NCTC 10418) and Staphylococcus aureus (NCTC 6571) by single-step passage at either four or eight times the MIC occurred at a frequency of less than 1 x 10(-10).
Foxall Pa +5 more
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Drugs, 1987
The in vitro activities of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were determined and a specific high performance liquid chromatography (HPLC) assay for these 3 compounds was devised as part of a study of the pharmacokinetics of ofloxacin and its metabolites in patients with impaired renal function.
Andrew M. Lovering +4 more
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The in vitro activities of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were determined and a specific high performance liquid chromatography (HPLC) assay for these 3 compounds was devised as part of a study of the pharmacokinetics of ofloxacin and its metabolites in patients with impaired renal function.
Andrew M. Lovering +4 more
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Journal of Antimicrobial Chemotherapy, 1988
Six patients with end-stage chronic renal failure undergoing haemodialysis were given ofloxacin (600 mg) orally and blood samples were taken at intervals up to 32 h. In four patients samples were also taken before and after haemodialysis. Serum concentrations of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were measured by HPLC.
L. O. White +3 more
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Six patients with end-stage chronic renal failure undergoing haemodialysis were given ofloxacin (600 mg) orally and blood samples were taken at intervals up to 32 h. In four patients samples were also taken before and after haemodialysis. Serum concentrations of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were measured by HPLC.
L. O. White +3 more
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Multiple dose kinetics of ofloxacin and ofloxacin metabolites in haemodialysis patients
European Journal of Clinical Pharmacology, 19927 patients with end-stage renal disease on regular haemodialysis were treated orally with a loading dose of 200 mg ofloxacin and multiple maintenance doses of 100 mg per 24 h for 10 days. The pharmacokinetics of ofloxacin and its metabolites were studied at the end of the treatment period.
Klaus Borner, D. Kampf, A. Pustelnik
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Chemical Communications, 2017
This study proposed a new and previously unconsidered reaction mechanism in the activation of peroxymonosulfate. We report that singlet oxygen (1O2) rather than ˙OH or SO4˙- was the dominant reactive oxygen species towards the efficient degradation of ...
Xike Tian +6 more
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This study proposed a new and previously unconsidered reaction mechanism in the activation of peroxymonosulfate. We report that singlet oxygen (1O2) rather than ˙OH or SO4˙- was the dominant reactive oxygen species towards the efficient degradation of ...
Xike Tian +6 more
semanticscholar +1 more source
2009
Publisher Summary This chapter describes ofloxacin, its general information, physical characteristics, analytical profiles, drug metabolism, and pharmacokinetics. Ofloxacin is a pale yellow or bright yellow crystalline powder, colorless needles from ethanol. The concentrate solution of the drug has a pH of 3.8–5.5 in aqueous. It is slightly soluble in
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Publisher Summary This chapter describes ofloxacin, its general information, physical characteristics, analytical profiles, drug metabolism, and pharmacokinetics. Ofloxacin is a pale yellow or bright yellow crystalline powder, colorless needles from ethanol. The concentrate solution of the drug has a pH of 3.8–5.5 in aqueous. It is slightly soluble in
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Primary Photophysical Properties of Ofloxacin¶
Photochemistry and Photobiology, 2000Steady-state fluorescence has been used to study the excited singlet state of ofloxacin (OFLX) in aqueous solutions. Fluorescence emission was found to be pH dependent, with a maximum quantum yield of 0.17 at pH 7. Two pKa*s of around 2 and 8.5 were obtained for the excited singlet state.
Jennifer Claridge, Suppiah Navaratnam
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The postantibiotic suppressive effect of l-ofloxacin, an optically active isomer of ofloxacin
Diagnostic Microbiology and Infectious Disease, 1992The postantibiotic suppressive effect (PAE) of L-ofloxacin was studied and compared with those of ciprofloxacin and norfloxacin. The PAE of L-ofloxacin was observed against all Gram-positive organisms tested: Staphylococcus aureus, S. epidermidis, and Enterococcus faecalis.
Kwung P. Fu +2 more
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