Results 41 to 50 of about 1,294,527 (246)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

The Amish Settlement in Honduras, 1968-1978: A (Half) Failed Attempt to Develop an Amish Understanding of Mission

open access: yesThe Journal of Amish and Plain Anabaptist Studies, 2016
For their several-hundred years of successfully maintaining Amish settlements in North America, for what reason would a group of families—largely from Nappanee, IN, and Aylmer, ON—want to start a settlement in Honduras? This account traces the genesis of
Cory Anderson
doaj  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Early History of the Holmes County Amish Community: An English Translation of L.A. Miller’s Ein Historischer Beright von den Alt-Amischen Gemeinden in Nord-Amerika [An Historical Account of the Old-Amish Communities in North America: Tuscarawas and Holmes Counties, Ohio]

open access: yesThe Journal of Amish and Plain Anabaptist Studies, 2019
This is a German-to-English translation of an old history article published in the Amish/Amish-Mennonite periodical, “Herald der Wahrheit” (“Harold of Truth”). L.A.
Gregory Sheets, Cory Anderson
doaj  

Entwicklung der cw-Laser-Frequenzmodulations-Spektroskopie zu einer Methode zur Messung von OH im troposphärischen Konzentrationsbereich

open access: yes, 2022
S.105-113Obwohl das OH-Radikal eine der wichtigsten reaktiven Substanzen der Atmosphäre ist, existieren bislang nur sehr wenige Meßaufbauten, die mit ausreichender Genauigkeit troposphärischer OH-Konzentrationen bestimmen können.
Zetzsch, C., Leonard, C.
core  

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Ordnungs Briefen of 1865, 1917, and 1939: English Translations of Important Old Amish Church Orders

open access: yesThe Journal of Amish and Plain Anabaptist Studies, 2019
This is a German-to-English translation of four important decisions made by Amish church leaders. The first, in 1865, was the charter agreement that launched the Old Order movement among the Amish, as the progressive Amish-Mennonites who had been ...
Dan Raber, Gregory Sheets, Cory Anderson
doaj  

METHODS OF NAVIGATING ALGORITHMIC COMPLEXITY: BIG-OH AND SMALL-OH NOTATIONS

open access: yesScientific Journal of Astana IT University, 2023
This article provides an in-depth exploration of Big-Oh and small-oh notations, shedding light on their practical implications in the analysis of algorithm complexity.
Zhanar Bimurat   +3 more
doaj   +1 more source

OH-SMART steps.

open access: yes, 2019
Overview of the six OH-SMART steps used to evaluate One Health Challenges.
Katelyn W. Macy (6919865)   +13 more
core   +1 more source

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