Results 131 to 140 of about 27,692,586 (192)

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

A Critical Time Window of Neocortex Modulation for Remote Fear Memory in Rats and Humans

Advanced Science, EarlyView.
This study identifies a delayed consolidation window around 18 h after fear learning in the mPFC essential for remote fear memory. VTA dopaminergic input during this window sustains remote memory in rats, while non‐invasive stimulation of homologous human mPFC at the corresponding time selectively weakens remote but not recent fear memory, revealing a ...
Lu Cao, Yu‐Xin Zhang, Xiao‐Xing Liu, Zi‐Hang Li, Tang‐Sheng Lu, Jia‐Hui Deng, Wen Zhang, Peng Li, Xiao Lin, Shu‐Fei Feng, Ting‐Ting Li, Shi‐Qiu Meng, Xiang‐Dong Tang, Tian‐Ye Jia, Trevor W. Robbins, Jie Shi, Ying Han, Yan‐Xue Xue, Lin Lu, Kai Yuan   +19 more
wiley   +1 more source

Multivariate multiscale complex network analysis of vertical upward oil-water two-phase flow in a small diameter pipe. [PDF]

Sci Rep, 2016
Gao ZK, Yang YX, Zhai LS, Dang WD, Yu JL, Jin ND.   +5 more
europepmc   +1 more source

Physical Simulation of Phase Separation at the Slag-Metal Interface During Pellet Melting: A Phenomenological Study. [PDF]

Materials (Basel)
Wang Y, Du Z, Song G, Chen L, Dang J, Chen C.   +5 more
europepmc   +1 more source

Optimization and Threshold of Soaking Time in Fracturing-Driven Huff-n-Puff for Tight Reservoirs Based on Dynamic Capillary Force. [PDF]

ACS Omega
Cheng Q, Huang N, An H, Wei J, Dai M, Zhou X, Bai Y.   +6 more
europepmc   +1 more source

Transient Transport and Flowback Behavior of Partitioning Tracers in Low-Permeability Reservoirs with a Hydraulically Fractured Vertical Well. [PDF]

ACS Omega
Liu J, Jiang L, Ma Y, Liu T, Liu S.
europepmc   +1 more source

Optimization and performance prediction of air-flotation cyclones for oily wastewater. [PDF]

RSC Adv
Huang Q, Xie Y, Yang Y, Shen Z, Wang R, Zhang X, Huang H, Tian Y, Long X.   +8 more
europepmc   +1 more source

Dynamic Occurrence and Mobilization Mechanisms of Condensate in Porous Media Revealed by Micro-CT and Two-Dimensional NMR. [PDF]

ACS Omega
Wang R, Wang F, Yan G, Wang S, Dai L, Ren X, Zhang C, Pei X, Zhang N, Zhu Z.   +9 more
europepmc   +1 more source