Results 121 to 130 of about 35,482 (264)

Rapid and Efficient Affinity Isolation of Engineered Extracellular Vesicles Encapsulating Functional Proteins via Internal Twin‐Strep Tetraspanin Tagging

open access: yesSmall, EarlyView.
Structure‐guided internal twin‐Strep tagging of the tetraspanins CD63 or CD9 enables rapid and efficient antibody‐free affinity isolation of engineered extracellular vesicles (EVs) using Strep technology while allowing luminal protein loading. The approach removes over 96% of contaminants, separates tagged EVs from coexisting viral particles, and ...
Minh‐Tu Pham   +14 more
wiley   +1 more source

Morphological Stabilization of CsPbBr3 Quantum Dot Films Enabled by PVC‐g‐PMMA Graft Copolymer Encapsulation for Water‐Robust Color Conversion

open access: yesSmall, EarlyView.
Poly(vinyl chloride)‐graft‐poly(methyl methacrylate) encapsulation enabled formation of water‐stable CsPbBr3‐quantum‐dot fims with enhanced photoluminescence (PL) retention upon exposure to water, UV radiation, and ethanol. Time‐dependent ex situ transmission electron microscopy with quantitative particle segmentation identified the coefficient of ...
Seung Ryeol Song   +6 more
wiley   +1 more source

Position Over Composition: Positional Isomerism Enables Encapsulation‐Independent Intrinsic Stability in a Conjugated Polymer

open access: yesSmall, EarlyView.
Repositioning side chains (para→meta) provides a composition‐invariant handle to program conjugated‐polymer chain geometry. The resulting worm‐like, kink‐suppressed conformation delivers >5× higher intrinsic photostability and enhanced resistance to energetic particle damage.
Eonji Kim   +11 more
wiley   +1 more source

Hydrogen‐bond‐mediated retention of a phenolic SNAP analogue in polyvinyl alcohol/PEG hydrogels for sustained nitric oxide release and antibacterial activity

open access: yesSmart Molecules, EarlyView.
A hydrogen‐bond‐donating NO donor was designed to interact specifically with the hydrogel network, thereby minimizing donor leakage and achieving prolonged NO release. Abstract Nitric oxide (NO)‐releasing materials have attracted considerable interest for their potential in diverse biomedical applications.
Yixin Zhu   +8 more
wiley   +1 more source

Smart mesoporous silica nanoparticles for precision cancer therapy: Tumor targeting and stimuli‐responsive controlled release

open access: yesSmart Molecules, EarlyView.
Smart mesoporous silica nanoparticles integrate tunable pore structures, molecular gates, targeting ligands, and stimuli‐responsive components to achieve controlled drug release for precision cancer therapy. This review highlights design principles, therapeutic applications, and future directions in immunotherapy, biodegradability, biosafety, and ...
Majdi Al‐Amili, Lei Lei, Zhu Jin
wiley   +1 more source

Microfluidic Molecular Diagnostic Chips: Functional Modules, Integration Strategies, and Emerging Applications

open access: yesSmall Methods, EarlyView.
This comprehensive review delivers an engineering‐centric analysis of microfluidic molecular diagnostic chips, breaking them down into foundational modules from fluid manipulation to bio‐sensing. Beyond chip design, it evaluates sample‐to‐answer integration strategies and commercial readiness levels.
Donghoon Koo   +7 more
wiley   +1 more source

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