Results 241 to 250 of about 362,144 (289)

Cinnamic‐Hydroxamic‐Acid Derivatives Exhibit Antibiotic, Anti‐Biofilm, and Supercoiling Relaxation Properties by Targeting Bacterial Nucleoid‐Associated Protein HU

Advanced Science, EarlyView.
Cinnamic‐hydroxamic‐acid derivatives (CHADs) are identified as novel inhibitors of the bacterial nucleoid‐associated protein HU, exhibiting potent antibacterial, anti‐biofilm (both inhibition and eradication), and DNA relaxation (anti‐supercoiling) activities. Moreover, CHADs demonstrate strong synergistic effects with multiple antibiotics.
Huan Chen, Yingqi Xu, Zhaoping Xiong, Hongliang Wang, Xin Wang, Yue Kang, Zhonglin Wang, Xiaoyan Zeng, Yahui Liu, Yehuan Zheng, Wei Chen, Mengzhe Li, Zhenyue Hu, Chi Xu, Yue Wu, Yawen Wang, Zuyi Yuan, Shuai Yuan, Huadong Liu, Steve Matthews, Nan Qiao, Yan Li, Bing Liu   +22 more
wiley   +1 more source

Nanotechnology strategies for enhancing productivity, sulphur use efficiency and soil fertility in groundnut-mustard cropping systems. [PDF]

Sci Rep
Yadav SL, Patel KC, Kumar D, Jinger D, Yadav LP, Birla D, Yadav M, Yadav RK, Yadav IR, Lakshman, Minkina T, Rajput VD, Yadav P, Meena VS.   +13 more
europepmc   +1 more source

The Osteoblastic Microenvironment Determines the Fate of Breast Cancer Cells Disseminated in the Bone Marrow

Advanced Science, EarlyView.
This study revealed how the osteoblastic microenvironment determines the fate of cancer cells disseminated in bone, with a focus on whether they colonize, reside in quiescence, or reactivate from dormancy. Targeting integrin signaling may offer promising strategies for preventing quiescent cancer cells reactivation and bone colonization.
Hong‐Li Wang, Rui Zhang, Xiao‐Min Yue, Jie Zhou, Yu‐Fan Huang, Rong Meng, Yu‐Li Wang, Xiao‐Qing Li   +7 more
wiley   +1 more source

Pyrrolidine Alkaloids from Mangrove Fungus <i>Penicillium</i> sp. DM27 Enhance L6 Cell Glucose Uptake. [PDF]

Mar Drugs
Fan FK, Zhang WT, Edjah PP, Tang QQ, Huang W, He LM, Zhou MQ, Tian CK, Zhu KK, Yang X, Cai YS, Hong K, Liu YZ.   +12 more
europepmc   +1 more source

Biodegradable Carbonate Nanogels Loaded with Anti MFAP‐5 siRNA for Anti‐stromal Therapy of Hepatocellular Carcinoma

Advanced Science, EarlyView.
Polycarbonate nanogels enable lipid‐free delivery of anti‐MFAP‐5 siRNA into cancer‐associated fibroblasts (CAF) in hepatocellular carcinoma. In a cirrhotic murine model, this approach silences MFAP‐5, reduces fibroblast activation, and suppresses tumor growth by inhibiting NOTCH/Hes1‐driven angiogenesis. CAF‐targeted MFAP‐5 RNAi and conserved signaling
Paul Schneider, Alexander Fuchs, Michael Fichter, Vanessa Bolduan, Jenny Schunke, Özlem Akilli, Nádia C. Correia, Yannick Ehlers, Christian Czysch, Pia Winterwerber, Eliana Stanganello, Barbara Schrörs, Mustafa Diken, Christoph Eckert, Shusruto Rishik, Andreas Keller, Jörn M. Schattenberg, Stephan Grabbe, Matthias Bros, Lutz Nuhn, Leonard Kaps   +20 more
wiley   +1 more source

Molecular Dynamics Simulation of Silicone Oil: Degradation upon Oscillatory Testing. [PDF]

Polymers (Basel)
Puhlmann P, Zahn D.
europepmc   +1 more source

Balanced Expression of the Diiron Oxygenase BioE Is Essential for Biotin Homeostasis in Elizabethkingia meningoseptica

Advanced Science, EarlyView.
BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang, Ying‐ying Fu, Xiaoqiang Yang, Qiuying Qin, Xinyu Su, Jiaming Fang, Yanhua Kang, Qingwen He, Zhi Ruan, Yongchang Xu   +9 more
wiley   +1 more source

Ameliorating quality and vase life of Solidago canadensis flowers via supplementation of eucalyptus, neem and rosemary as phyto-preserver oils. [PDF]

BMC Plant Biol
El-Sayed IM, Mohamed El-Ziat RA, Saudy HS, Hewidy M.   +3 more
europepmc   +1 more source

Correction: African walnut (<i>Plukenetia conophora</i>) oil improves glucose uptake and metabolic activities in erythrocytes. [PDF]

Front Nutr
Erukainure OL, Chukwuma CI.
europepmc   +1 more source

Zinc-based agronomic bio-fortification strategies for soybean in the North Eastern Himalayas of India. [PDF]

Sci Rep
Makdoh B, Singh AP, Zhiipao RR, Biswakarma N, Nayak S, Sangma CBK, Aochen C, Jamir A, Touthang L, Angami T, Solo V, Singh LS, Nongmaithem D, Jamir S, Ozukum C, Thinley P, Newmai ZK.   +16 more
europepmc   +1 more source