Results 91 to 100 of about 2,666 (255)

Hepatic Lipid Stress Drives Metabolic Dysfunction‐Associated Steatohepatitis Progression through FTO O‐GlcNAcylation‐Induced m6A Demethylation of HRAS

Advanced Science, EarlyView.
Lipid stress drives O‐GlcNAcylation of the m6A demethylase FTO at Ser195, enhancing its stability and demethylase activity. This modification removes m6A from HRAS mRNA, preventing its degradation and activating PI3K/AKT signaling to promote hepatic steatosis and inflammation.
Jia‐Xin Yin, Yan‐Lai Zhang, Qun Liu, Rui Liu, Hai‐Yang Yuan, Sui‐Dan Chen, Ming‐Hua Zheng, Kai Wang, Ni Tang, Ai‐Long Huang   +9 more
wiley   +1 more source

Rural Labor Supply and Economic Opportunities: Commuting, Migration, Tariffs, and Immigration

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT Some rural counties remain dependent on agricultural or manufacturing jobs, but an increasing proportion have diversified economics. Rural counties also differ in their abilities to commute to an urban market characterized by higher wages and labor productivity.
Peter F. Orazem, Mary C. Ahearn
wiley   +1 more source

Impact of Postoperative Infectious Complications on Long‐Term Survival After Curative Resection for Colorectal Cancer: A Multicenter Study in the Minimally Invasive Era

Annals of Gastroenterological Surgery, EarlyView.
Postoperative infectious complications (PICs) have been associated with poor long‐term outcomes after colorectal cancer surgery, but evidence in the modern minimally invasive era remains limited. In this multicenter cohort of 5377 patients undergoing curative resection, PICs were independently associated with worse overall survival and relapse‐free ...
Takehito Yamamoto, Ryosuke Mizuno, Yoshiro Itatani, Tetsuya Shiota, Masahiro Yamada, Tadayoshi Yamaura, Mami Yoshitomi, Kazutaka Obama   +7 more
wiley   +1 more source

Essential Updates in the Surgical Management of Inflammatory Bowel Disease: Current Topics From 2024 to Mid‐2026

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Inflammatory bowel disease management has undergone a major transformation with the introduction of treat‐to‐target strategies and highly effective biologic and small‐molecule therapies. Although these advances have reduced the overall requirement for surgery, operative intervention remains essential for selected patients with ulcerative ...
Yoshiki Okita, Tadanobu Shimura, Mikio Kawamura, Yuhki Koike, Yuji Toiyama   +4 more
wiley   +1 more source

Beyond Nature's Blueprint: Macrocyclic Peptides Containing Unnatural Amino Acids in Therapeutic Development

Angewandte Chemie, EarlyView.
Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma, Komal Sharma, Anku Sharma, Kamya Rao, Rahul Jain, Brett VanVeller   +5 more
wiley   +2 more sources

Ointment Bases.

Indian journal of dermatology, venereology and leprology
Local medications are important in any dermatological prescription. For optimum results at reasonable cost such medications are best,' tailor made.' Absolute dependence on commercially available preparations severely restricts the freedom, of the practicing dermatologist.
openaire   +1 more source

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer?

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have been reported in a subset of pMMR tumors, suggesting that clinical ...
Kimihiro Yamashita, Takeru Matsuda, Junko Mukohyama, Ryohei Sasaki, Yoshihiro Kakeji   +4 more
wiley   +1 more source

Soft Interactions, Rather Than Crowder Size, Determine Deviations From Arrhenius‐Like Kinetics of Phosphofructokinase‐1

Angewandte Chemie, EarlyView.
Our study investigates macromolecular crowding effects in the Arrhenius‐like and non‐Arrhenius temperature regimes of the human platelet isoform of phosphofructokinase‐1 (PFKP). The results reveal how PFKP maintains temperature robustness of catalytic activity in differently crowded environments.
Harshita Rastogi, Madhav Samanta, Truong‐An Nguyen, Mehrnoosh Khodam Hazrati, Bradley A. Webb, Eva Pluhařová, Stepan Timr, Simon Ebbinghaus   +7 more
wiley   +2 more sources

Accounting for animal health in efficiency analysis: An application to Swedish dairy farms

American Journal of Agricultural Economics, EarlyView.
Abstract Poor animal health is a central concern in modern livestock production. Despite the necessity to incorporate animal health in efficiency analysis, the theoretical and empirical developments are limited on this subject. This article appropriately characterizes the axiomatic properties of animal health within a production framework.
Frederic Ang, Enoch Owusu‐Sekyere, Karin Alvåsen, Helena Hansson   +3 more
wiley   +1 more source

Electro‐Organic Synthesis at a Stable Oil/Water/Solid Three‐Phase Interface Reactor

Angewandte Chemie, EarlyView.
A porous membrane electrode (PME) reactor is developed to promote oil/water/solid three‐phase interfacial contact for electro‐organic synthesis. By promoting the formation of an oil/water interfacial region within or near an amphiphilic catalytic layer, the reactor enables efficient conversion of water‐insoluble organic reactants in aqueous ...
Deyin Chen, Jianan Zhu, Huan Wu, Huajun Zheng, Longhao Jiao, Chengpu Chu, Yinghua Xu, Bin Liu   +7 more
wiley   +2 more sources