Results 201 to 210 of about 8,613,677 (243)

MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice

Arthritis &Rheumatology, Accepted Article.
Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez, Pranay Ramteke, Bahiyah Watson, Owen Haslam, Eirene Choi, Susan Chubinskaya, Mandy J. Peffers, William R. Davis, Jacqueline Shine, Brian O. Diekman, Richard F. Loeser, Theresa A. Freeman, Makarand V. Risbud, John A. Collins   +13 more
wiley   +1 more source

Biodiversity resilience in a tropical rainforest. [PDF]

Nature
Metz T, Farwig N, Dormann CF, Schaefer HM, Guevara-Andino JE, Brehm G, Burneo S, Chao A, Chazdon RL, Colwell RK, Diniz UM, Donoso DA, Endara MJ, Erazo S, Escobar S, Falconí-López A, Feldhaar H, Villamarin MG, Grella N, Heer K, Heethoff M, Keller A, Landim AR, Leonhardt SD, Lopez ET, Marín-Armijos D, Müller J, Neira-Salamea K, Neuschulz EL, Pedersen KM, Rödel MO, Schleuning M, Schmitt T, Staab M, Tartara A, Tinoco BA, Tremlett CJ, Tschapka M, Unsicker S, Villa-Galaviz E, Blüthgen N.   +40 more
europepmc   +1 more source

Dissecting the dissection laboratory: Elements for designing a human anatomy laboratory

Anatomical Sciences Education, EarlyView.
Abstract The human anatomy dissection laboratory is a critical component of anatomical and medical education. Development, maintenance, and stocking of these laboratory spaces have unique demands, with all of the challenges in running a laboratory with Biosafety Laboratory Level 2 (BSL‐2) classification, housing a large volume of tissues saturated with
Rhiannon E. Robinson, Abbey Breckling, Danielle N. Edwards, Nicole Geske, Burhan Gharaibeh, Bobbie J. Leeper, Molly Ostwald, Mary Schilling, Bridgett Severt, Kelsey Stevens, J. P. Swigart, Jonathan J. Wisco, Melissa Zolnierz, Jeremy J. Grachan   +13 more
wiley   +1 more source

Data, not documents: Moving beyond theories of information‐seeking behavior to advance data discovery

Journal of the Association for Information Science and Technology, Volume 76, Issue 4, Page 649-664, April 2025.
Abstract Many theories of human information behavior (HIB) assume that information objects are in text document format. This paper argues four important HIB theories are insufficient for describing users' search strategies for data because of assumptions about the attributes of objects that users seek.
Anthony J. Million, Jeremy York, Sara Lafia, Libby Hemphill   +3 more
wiley   +1 more source

Old Soil Organic Matter Has a Low Carbon:Nitrogen Ratio-A Global Meta-Analysis About ¹⁴C and Soil Stoichiometry. [PDF]

Glob Chang Biol
Spohn M.
europepmc   +1 more source

Comparative efficacy of GLP‐1 RA, tirzepatide and SGLT‐2 inhibitors in metabolic liver disease: A network meta‐analysis

British Journal of Clinical Pharmacology, EarlyView.
Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić, Christina Antza, Anastasios Poutachidis, Smaro Palaska, Elvira Meni Maria Gkrinia, Andrea Katrin Faour, Yusuf Ziya Sener, Seher Sener, Rehena Sultana   +8 more
wiley   +1 more source

Study on the canopy structure and light distribution of <i>Hippophae rhamnoides</i> at different ages. [PDF]

Front Plant Sci
Tan K, Wang Y, Yan G, Zhang L, Lei J, Wang J, Wang Y, Dong X, Tang C, Jin Q.   +9 more
europepmc   +1 more source

When meta‐analyses mislead: Promises and pitfalls in teratology counselling

British Journal of Clinical Pharmacology, EarlyView.
Meta‐analysis has become a central tool for evidence synthesis in clinical teratology, offering the promise of increased statistical power, earlier signal detection and consolidated guidance for teratology counselling. When conducted rigorously and interpreted carefully, pooled analyses can provide clinicians with a structured basis for risk ...
Yusuf Cem Kaplan, Nusret Uysal
wiley   +1 more source

Recent high-severity wildfires in a dry-conifer landscape are unprecedented over five centuries and foretell future forest loss. [PDF]

Proc Natl Acad Sci U S A
Wion AP, Stevens JT, Coop JD, Farris CA, Parks SA, Allen CD, Margolis EQ.   +6 more
europepmc   +1 more source

The quality of interaction with children in collective play: Children's agency

British Educational Research Journal, EarlyView.
Abstract There is a growing body of studies on increasing the quality of infant–toddler education and care. Yet little attention has been directed towards how to bring toddlers' agency and perspective to their personally meaningful learning in collective play.
Liang Li
wiley   +1 more source