Results 81 to 90 of about 8,613,677 (243)

Loss of SHP1 in Spinal Astrocytes Triggers T‐Lymphocyte Infiltration and Nociceptive Hypersensitivity

Advanced Science, EarlyView.
Astrocyte‐specific SHP1 deletion disrupts astrocyte–vascular interactions and compromises BBB integrity while enhancing STAT1‐dependent CXCL10 expression. These changes synergistically promote peripheral CD4+ and CD8+ T‐cell infiltration into the SDH. The infiltrating T cells secrete IFN‐γ, which in turn activates microglia.
Lan‐Xing Yi, Lin Yang, Kang‐Li Wang, Hui‐Zhu Liu, Rui‐Ying Chen, Min Su, Xiao Xiao, Yu‐Qiu Zhang   +7 more
wiley   +1 more source

Vegetation indices monitoring by using copernicus data in the old-growth forests of the Republic of Srpska/Bosnia and Herzegovina

Frontiers in Forests and Global Change
IntroductionOld-growth forests (OGFs) are vital for global biodiversity, acting as irreplaceable carbon sinks, fostering ecosystem stability, and preserving unique ecological and cultural heritage.
Zoran Govedar, Nemanja Anikić
doaj   +1 more source

Ecological Drivers of the Soil Microbial Diversity and Composition in Primary Old-Growth Forest and Secondary Woodland in a Subtropical Evergreen Broad-Leaved Forest Biome in the Ailao Mountains, China. [PDF]

Front Microbiol, 2022
Zeng Q, Lebreton A, Man X, Jia L, Wang G, Gong S, Buée M, Wu G, Dai Y, Yang Z, Martin FM.   +10 more
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Climate sensitivity of radial growth in European beech (Fagus sylvatica L.) at different aspects in southwestern Germany [PDF]

, 2011
The climate sensitivity of radial growth in European beech (Fagus sylvatica L.) was analyzed within a narrow valley in the Swabian Alb (southwestern Germany).
van der Maaten, Ernst, Maaten, Ernst van der, Ernst van der Maaten   +2 more
core   +1 more source

Soil microbial community responses to active and passive restoration of selectively logged Bornean tropical forest

Frontiers in Microbiology
Tropical rainforests support critical biogeochemical cycles regulated by complex plant-soil microbial interactions but are threatened by global change.
Samuel J. B. Robinson, Samuel J. B. Robinson, Dafydd M. O. Elias, Tim Goodall, Niall P. McNamara, Robert Griffiths, Noreen Majalap, Yap Sau Wai, Nicholas J. Ostle   +8 more
doaj   +1 more source

Changes in beta diversity and species functional traits differ between saplings and mature trees in an old-growth forest. [PDF]

Ecol Evol, 2021
Kirk DA, Brice MH, Bradstreet MS, Elliott KA.   +3 more
europepmc   +1 more source

METTL7A Downregulation Drives SLC1A5‐Mediated Glutamine Competition to Promote Tumor Proliferation and Suppress CD8+ T Cell Immunity in Gastric Cancer

Advanced Science, EarlyView.
GC cells enhance glutamine accumulation by upregulating SLC1A5 expression. This upregulation not only boosts GC cell proliferation, but also outcompetes CD8+ T cells for glutamine and suppresses their antitumor immunity. Mechanistically, METTL7A deficiency in GC induces SLC1A5 overexpression via an m6A‐dependent pathway and N‐glycosylation ...
Mingjun Sun, Shuwei Dang, Dazhi Zhou, Lixian Ding, Xun Sun, Wei Suo, Jirui Niu, Qingzhu Yang, Zhicheng Zhang, Yanyan Sun, Jinxing Li, Zhongsheng Chen, Tao Ban, Yingji Wang, Tianzhu Li, Ming Liu, Guodong Li   +16 more
wiley   +1 more source

Effects of continuous cover management on bird communities in a beech dominated forest region of Slovenia

Scientific Reports
Forest management can have a negative impact on the populations of some forest species. One solution has been to use management that is better at mimicking natural processes.
Małgorzata Bujoczek, Leszek Bujoczek, Thomas A. Nagel   +2 more
doaj   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source