Results 121 to 130 of about 1,315,916 (261)
Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT
Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...Moran Hausman‐Kedem, Noa Bielopolski, Vijai Krishnan, Shane Wald‐Altman, Shelly I Shrian, Omer Bar‐Yosef, Livia Kapusta, Claire Shamber, Patricia L. Musolino, Miguel Weil +9 morewiley +1 more sourceStructural Attributes Outweigh Topographical Effects in Determining Vascular Plant Diversity Within Southern Apennine Old-Growth Forests. [PDF]
Ecol EvolTravascia D, Piovesan G, Passalacqua N, Borghetti M, Bernardo L, Burrascano S, Colangelo M, Fiorentino C, Gargano D, Lapolla A, Marchianò V, Rivelli AR, Schettino A, Ripullone F. +13 moreeuropepmc +1 more sourceCSF Cytokine Network Organization Predicts Progression Independent of Relapse and MRI Activity in Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...Antonio Bruno, Matteo Conti, Ettore Dolcetti, Federica Azzolini, Angela Borrelli, Roberta Fantozzi, Mario Stampanoni Bassi, Giovanni Galifi, Giuseppe Maccarrone, Luca Montaguti, Marco Cervigni, Maddalena Dal Pozzo, Roberto Furlan, Annamaria Finardi, Girolama Alessandra Marfia, Marco Salvetti, Antonella Conte, Fabio Buttari, Diego Centonze, Luana Gilio +19 morewiley +1 more sourceRegion-specific forest structure pathways reveal climate effects on old-growth tropical forest biomass. [PDF]
Sci RepDepoortere P, Bauman D, Fayolle A, Phillips O, Bialic-Murphy L, Zohner CM, Vander Linden A, Plumacker A, de Lame H, Liang J, Reich PB, Gamarra JGP, Alberti G, Hérault B, Picard N, de-Miguel S, Nabuurs GJ, Crowther TW, Paquette A, Pretzsch H, Wiser SK, Zhou M, Chen HYH, Verbeeck H, De Cannière C, Sullivan MJP, Poorter L, Ponette Q, Bauters M, Deblauwe V, Keppel G, Brearley FQ, Zo-Bi IC, Ouattara TA, Lawes MJ, Bongers F, Meave JA, Schulze M, Ngoh ML, Ter Steege H, Homeier J, Azihou AF, Trethowan L, Slik JWF, Derroire G, Bonal D, Laurance WF, Hemp A, Murdjoko A, Aguirre-Gutiérrez J, Kintamani E, White L, Lewis SL, Hector A, Amani C, Andrade A, Angbonga A, Aragão L, Kurian A, Allah Barem F, Almeyda Zambrano AM, Alvarez-Davila E, Alvarez-Loayza P, Amstrong E, Araujo-Murakami A, Arroyo L, Baker TR, Bako O, Bánki O, Baraloto C, Barbier N, Barroso JG, Bassama P, Beeckman H, Benu NMH, Bihiya H, Birnbaum P, Bitariho R, Boeckx P, Boekee K, Bogaert J, Böhning-Gease K, Boyemba F, Brandão da Cunha H, Brienen R, Briseño-Reyes J, Broadbent EN, Camargo JL, Cassart B, Cazzolla Gatti R, Chave J, Chuyong G, Clark DB, Clark C, Collalti A, Collins M, Cornejo Valverde F, Corral-Rivas JJ, Couteron P, Cuni-Sanchez A, da Costa L, Daniel Soto J, Dar AA, Dar JA, Dauby G, de Haulleville T, Di Fiore A, Diisi J, Djuikouo K MN, Dolezal J, Dongmo N, Doucet JL, Droissart V, Engel J, Engone Obiang NL, Espinosa S, Eyre T, Fauset S, Feldpausch TR, Fischer M, Gajapersad K, Girmansyah D, Gloor E, Gomes do Amaral I, Gonmadje CF, Grieco E, Grogan J, Habonayo R, Harris DJ, Honorio Coronado E, Huamantupa-Chuquimaco I, Hubau W, Jansen PA, Jeffery KJ, Jumbam B, Kanda NB, Kamdem N, Kasongo Yakusu E, Katembo J, Kayijamahe C, Kearsley E, Kenfack D, Khan ML, Killeen T, Kothandaraman S, Kougue R, Kumar A, Kuswandi R, Labrière N, Lasso D, Laurance S, Leal M, Leblanc H, Libalah M, Lisingo J, Malhi Y, Marimon BS, Marimon Junior BH, Marshall AR, Martin EH, Martin-Ducup O, Mbasi MM, Mbayu F, Mendoza C, Mendoza Polo I, Mofack G, Monteagudo-Mendoza A, Mtui A, Muthuramkumar S, Narayanan A, Nava-Miranda MG, Neill D, Neldner VJ, Tchatchouang EN, Ngoula F, Ngugi MR, Sainge MN, Núñez Vargas P, Ortiz-Malavassi E, Pallqui Camacho N, Pandi V, Parada Gutierrez GA, Pardo G, Parthasarathy N, Pelissier R, Pfautsch S, Pijanowski BC, Piotto D, Pipoly J, Pitman N, Ploton P, Poulsen JR, Ramesh BR, Ramirez Arevalo F, Ramírez-Angulo H, Rasingam L, Réjou-Méchain M, Restrepo Correa Z, Spironello WR, Rodrigues de Souza C, Rodriguez LO, Rolim S, Roopsind A, Rovero F, Sagang LB, Saikia P, Salis A, Salla BP, Silva Espejo JE, Silveira M, Simo-Droissart M, Sirri N, Sonké B, Sundarapandian S, Swaine M, Swanepoel B, Taedoumg H, Tcheferi I, Terborgh J, Thomas D, Thomas R, Tshibamba Mukendi J, Umunay PM, Valencia R, Valenzuela Gamarra L, Valle Ferreira L, van der Heijden G, Vasquez Martinez R, Vega-Nieva JD, Vilanova E, Vilchez Alvarado B, Vinceti B, Vleminckx J, von Gadow K, Vos VA, Wasingya E, Watson J, Wortel V, Zagt R, Zébazé D, ForestPlots.net, GFBI, Bastin JF. +242 moreeuropepmc +1 more sourceEvaluation of Dried Plasma Spot‐Based Quantification of Glial Fibrillary Acidic Protein as a Disease‐Associated Biomarker in Neuromyelitis Optica Spectrum Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
To evaluate the diagnostic accuracy of glial fibrillary acidic protein (GFAP) measured in dried plasma spots versus conventional plasma‐ and serum‐GFAP testing for assessment of disease severity in aquaporin‐4 immunoglobulin G–positive neuromyelitis optica spectrum disorder (AQP4‐IgG+ NMOSD).Felix Wohlrab, Evelyn Alvarez, Roua Hamdi, Bingqing Zhang, Hayeun Ji, Niyati Jhaveri, Patrick Schindler, Pedro Sanchez, Pia S. Sperber, Tanja Schmitz‐Hübsch, Frederike C. Oertel, Nisa Vorasoot, Najib Kissani, Falko Böhringer, Jens Kuhle, Anne‐Katrin Pröbstel, Xiao‐Jun Ma, Péter Körtvelyessy, Patrick Waters, Friedemann Paul +19 morewiley +1 more sourceDiffuse MRI Edema Predicts Relapse in Cerebral Amyloid Angiopathy–Related Inflammation
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective
To identify MRI predictors of relapse and quantify relapse and mortality risk in cerebral amyloid angiopathy–related inflammation (CAA‐RI). A secondary objective was to assess the association between mycophenolate mofetil use and relapse risk. Methods
We performed a retrospective cohort study of 36 patients with CAA‐RI treated at the G. Abbas Kharal, Gowtham Yerneni, Kim J. Griffin, Nicolas Thompson, Ken Uchino, Irene Katzan, Dolora Wisco, Abeer Farrag, Jayashree Sundarajan, Andrew Russman, M. Shazam Hussain +10 morewiley +1 more source
