Results 91 to 100 of about 62,858 (261)

Second-growth forests of the Mexican tropics are reservoirs of timber species similar to old-growth forest: Perspectives for sustainable forest management

open access: yesTrees, Forests and People
Second-growth forests represent the largest area of forest in southern Mexico and can provide relevant information on how their structural attributes in are linked to anthropogenic factors and for their forest management. However, a knowledge gap remains
Ramiro Puc-Kauil   +9 more
doaj   +1 more source

Neuron‐Derived MIF Engages VCAM1 to Fuel a Self‐Amplifying CXCL8 Loop That Drives Perineural Invasion and Metastasis in Gastric Cancer

open access: yesAdvanced Science, EarlyView.
Neuron‐derived MIF binds VCAM1 on gastric cancer cells and activates ERK/STAT3 signaling, leading to CXCL8 transcription and secretion. Tumor‐derived CXCL8 subsequently stimulates neuronal CXCR2 to enhance MIF production, establishing a self‐amplifying MIF–VCAM1–CXCL8 positive‐feedback loop that promotes perineural invasion, tumor progression, and ...
Xunjun Li   +13 more
wiley   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

open access: yesAdvanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang   +10 more
wiley   +1 more source

Biodiversity in primary vs. managed forests: Biological legacies of old living and large dead trees drive lichen diversity

open access: yesForest Ecosystems
Anthropogenic activities have significantly contributed to the loss and fragmentation of primary forests across the globe, which has accelerated biodiversity decline, particularly among highly specialised species dependent on unique forest structures ...
Daniela Dúhová   +15 more
doaj   +1 more source

Targeting WDR12 Unleashes T‐Cell‐Mediated Antitumor Activity in Melanoma by Destabilizing CD276

open access: yesAdvanced Science, EarlyView.
WDR12 cooperates with the chaperonin subunit CCT7 to maintain CD276 stability on tumor cells, suppressing T‐cell activity and promoting immune escape. SU14813, a small‐molecule WDR12 inhibitor, reduces CD276 stability and relieves CD276‐mediated T‐cell suppression.
Jie Pan   +10 more
wiley   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

open access: yesAdvanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong   +20 more
wiley   +1 more source

Carbon‐Water Tradeoffs in Old‐Growth and Young Forests of the Pacific Northwest

open access: yesAGU Advances
Despite much interest in relationships among carbon and water in forests, few studies assess how carbon accumulation scales with water use in forested watersheds with varied histories.
Michael D. Farinacci   +2 more
doaj   +1 more source

Deep Learning Network‐Tailored Microenvironment Matching of 4D Bioprinting Bioactive Scaffolds for Bone Regeneration

open access: yesAdvanced Science, EarlyView.
A DLN dataset was built to analyze MABS composition versus in vitro/in vivo osteogenesis and angiogenesis. An MLP neural network, taking BG morphological parameters as input, extracts bioactive features from these datasets. A rabbit tibial defect model then validates 4D‐printed MABS for adaptability and bone regeneration in critical defects.
Xiongjie Liang   +12 more
wiley   +1 more source

Rewilding beech-dominated temperate forest ecosystems: effects on carbon stocks and biodiversity indicators

open access: yesiForest - Biogeosciences and Forestry
Maximising carbon stock and habitat availability is a critical objective of contemporary forest management, with primary forests serving a crucial function due to their substantial carbon storage potential and biodiversity values.
Markuljaková K   +18 more
doaj   +1 more source

Rhizosphere activity in an old-growth forest reacts rapidly to changes in soil moisture and shapes whole-tree carbon allocation. [PDF]

open access: yesProc Natl Acad Sci U S A, 2020
Joseph J   +28 more
europepmc   +1 more source

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