Results 201 to 210 of about 7,552,045 (259)
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem +9 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To determine whether discontinuing anti‐CD20 therapy in people with relapsing‐onset MS aged over 50 is associated with an increased risk of relapse, inflammatory activity, confirmed disability accrual, and serious infection compared with continuing therapy.
Alexia Moukhine +40 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous neurodegenerative disease requiring reliable biomarkers to improve patient stratification and trial design. While serum neurofilament light chain (sNfL) reflects neuroaxonal stress and disease aggressiveness, troponin T (TnT) may capture complementary aspects of ...
Julia Sellin +8 more
wiley +1 more source
Posterior Disconnection Syndrome in Early‐Stage Adult‐Onset Cerebral Adrenoleukodystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Adult‐onset cerebral adrenoleukodystrophy is potentially treatable but often difficult to recognize before advanced cerebral involvement. Herein, we describe three men with early‐stage disease who initially presented with subtle visual complaints rather than subcortical dementia. Targeted neuropsychological testing revealed higher‐order visual
Kazuto Katsuse +13 more
wiley +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Progression independent of relapse activity is a major determinant of long‐term disability in multiple sclerosis, but its immunopathologic basis remains incompletely understood. We investigated whether relapse‐independent progression in radiologically stable relapsing–remitting multiple sclerosis is associated with distinct ...
Antonio Bruno +19 more
wiley +1 more source
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British Medical Bulletin, 1990
All practising clinicians will be aware of the increased number of elderly patients requiring drug treatment as the proportion of people over the age of 65 increases in our Western society. The elderly as a group have much to benefit from modern drug therapy, but, historically, are also the group most prone to adverse drug reactions.
B F, Tregaskis, L H, Stevenson
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All practising clinicians will be aware of the increased number of elderly patients requiring drug treatment as the proportion of people over the age of 65 increases in our Western society. The elderly as a group have much to benefit from modern drug therapy, but, historically, are also the group most prone to adverse drug reactions.
B F, Tregaskis, L H, Stevenson
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Journal of the American Geriatrics Society, 1978
ABSTRACT: We are increasingly becoming a society of older people. The most prevalent emotional disturbance in this group is depression. Its management is an urgent concern to professionals in the mental health field.
L B, Fassler, M, Gaviria
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ABSTRACT: We are increasingly becoming a society of older people. The most prevalent emotional disturbance in this group is depression. Its management is an urgent concern to professionals in the mental health field.
L B, Fassler, M, Gaviria
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Scandinavian Audiology, 1991
From the gerontological and geriatric study of 70-year-olds in Göteborg, Sweden, 674 persons were selected to participate in an investigation of tinnitus in old age. The subjects belonged to two cohorts, one of which was followed longitudinally at ages 75 and 79. Some 8-15% of the participants had continuous tinnitus and 20-42% occasional tinnitus. The
U, Rosenhall, A K, Karlsson
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From the gerontological and geriatric study of 70-year-olds in Göteborg, Sweden, 674 persons were selected to participate in an investigation of tinnitus in old age. The subjects belonged to two cohorts, one of which was followed longitudinally at ages 75 and 79. Some 8-15% of the participants had continuous tinnitus and 20-42% occasional tinnitus. The
U, Rosenhall, A K, Karlsson
openaire +2 more sources
Journal of the American Geriatrics Society, 1971
It is when the human heart faces its destiny and notwithstanding sings—sings of itself, its life, its death—that poetry is possible.—Archibald Mac‐Leish.
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It is when the human heart faces its destiny and notwithstanding sings—sings of itself, its life, its death—that poetry is possible.—Archibald Mac‐Leish.
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The Family Coordinator, 1978
Although an increasing number of elders in the United States are remarrying, remarriage has been among the least researched and least known alternatives in old age. This paper explores some social, situational and personal factors associated with remarriage in old age, and focuses on role changes associated with remarriage.
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Although an increasing number of elders in the United States are remarrying, remarriage has been among the least researched and least known alternatives in old age. This paper explores some social, situational and personal factors associated with remarriage in old age, and focuses on role changes associated with remarriage.
openaire +2 more sources