Results 101 to 110 of about 294,537 (308)

Pure ones: the WˁB AND WˁBT from the old Kingdom to the end of the middle kingdom

open access: yes, 2014
This thesis explores the development of the wˁb-title from the Old Kingdom to the end of the Middle Kingdom. During the Old Kingdom, 59% of title-holders are linked to the royal mortuary cult, many of whom were promoted to the upper-ranking office of ḥm ...
Wilson, Amy
core  

β‐Elemene Rescues Radiation‐Induced Enteritis by Orchestrating a Host‐Microbiome Circuit That Fuels Epigenetic DNA Repair

open access: yesAdvanced Science, EarlyView.
This study elucidates that β‐elemene promotes cellular uptake of L. gasseri‐derived lactate by enhancing the membrane translocation of MCT1 in a CD147‐dependent manner. Intracellular lactate, through the lactylation of RBBP4 at the K26 site, recruits EP300 to the promoter regions of downstream genes (POLD1/POLD3), catalyzing H3K27ac modification.
Jiancheng He   +10 more
wiley   +1 more source

Stress History Establishes a Transient Tolerant State That Shapes Antibiotic Survival Upon Resuscitation

open access: yesAdvanced Science, EarlyView.
High‐throughput single‐cell analysis of resuscitating bacteria reveals a starvation‐history‐dependent transiently tolerant subpopulation that survives β$\beta$‐lactam exposure by temporarily reducing growth. Distinct from classical persisters, these actively growing yet dynamically modulated cells dominate survival across clinically relevant antibiotic
Kieran Abbott   +5 more
wiley   +1 more source

Two Routes to Land: Genomic Underpinnings of Parallel Aerial Egg Deposition in Aquatic Old‐World Pila and New‐World Pomacea (Ampullariidae)

open access: yesAdvanced Science, EarlyView.
Comparative genomics of Gondwana‐diverged Pila and Pomacea reveals parallel evolution of aerial oviposition. Convergent chromosomal rearrangements reshape regulatory landscapes within topologically associating domains. Lineage‐specific gene family expansions and viral‐derived perivitelline proteins (PV1) underpin desiccation resistance.
Yufei Zhou   +10 more
wiley   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

open access: yesAdvanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong   +24 more
wiley   +1 more source

Behaviour(s) of lower status individuals in Old Kingdom Egypt

open access: yes, 2022
Ancient Egyptian private tombs unveil face-to-face interchanges depictions in the so-called daily-life scenes. They include short texts written as if spoken with a deliberate choice of linguistic features.
Motte, Aurore
core  

The tomb of Khuwy at Djedkare’s royal cemetery at South Saqqara. Preliminary report on the 2019 spring season [PDF]

open access: yesPražské Egyptologické Studie, 2019
The royal necropolis surrounding the pyramid complex of Djedkare at South Saqqara is largely unexplored. In the 2019 spring season, the Egyptian mission uncovered a large mastaba in the north-east part of the necropolis.
Mohamed Megahed, Hana Vymazalová
doaj  

Glomage: A Multimodal Platform for High‐Content Morphological and RNA Profiling of Glomeruli in Zebrafish and Mouse Models

open access: yesAdvanced Science, EarlyView.
Understanding how glomeruli, the kidney's filtration units, function in intact tissue remains challenging. Glomage enables rapid 3D imaging and quantitative analysis of entire glomeruli from zebrafish larvae and mice. This approach allows scalable cell quantification and detection of structural changes, advancing kidney disease research and ...
Maximilian Schindler   +4 more
wiley   +1 more source

Revisiting the Old Kingdom at Thebes: Extracting meaning from highly fragmentary evidence

open access: yes
The ‘tomb complex’ that developed over time around the New Kingdom tomb of Neferhotep in el-Khokha comprises TT49 (the main tomb), TT187, TT362, TT363, and Kampp -347- and -348-.
Lemos, Rennan   +2 more
core   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

open access: yesAdvanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressotti   +15 more
wiley   +1 more source

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