Results 1 to 10 of about 1,853 (104)

Positive association between Toxoplasma gondii IgG serointensity and current dysphoria/hopelessness scores in the Old Order Amish: a preliminary study [PDF]

Pteridines, 2017
Toxoplasma gondii (T. gondii) IgG seropositivity and serointensity have been previously associated with suicidal self-directed violence (SSDV). Although associations with unipolar depression have also been investigated, the results have been inconsistent,
Wadhawan Abhishek, Dagdag Aline, Duffy Allyson, Daue Melanie L., Ryan Kathy A., Brenner Lisa A., Stiller John W., Pollin Toni I., Groer Maureen W., Huang Xuemei, Lowry Christopher A., Mitchell Braxton D., Postolache Teodor T.   +12 more
doaj   +3 more sources

Associations of genome-wide and regional autozygosity with 96 complex traits in old order Amish [PDF]

BMC Genomics, 2023
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is typically measured from runs of homozygosity
Megan T. Lynch, Kristin A. Maloney, Huichun Xu, James A. Perry, Regeneron Genetics Center, Alan R. Shuldiner, Braxton D. Mitchell   +6 more
doaj   +2 more sources

Phenotypic Variability in Atherosclerosis Burden in an Old-Order Amish Family With Homozygous Sitosterolemia [PDF]

JACC: Case Reports, 2020
Sitosterolemia is a rare atherogenic sterol storage disease with variability in its presentation requiring a high degree of clinical suspicion. We present 8 cases of sitosterolemia from an Amish kindred that, despite a background of decreased genetic and
Amy L. Peterson, MD, James DeLine, MD, Claudia E. Korcarz, DVM, Ann M. Dodge, RN, MSN, CPNP, James H. Stein, MD   +4 more
doaj   +2 more sources

Seasonality of blood neopterin levels in the Old Order Amish [PDF]

Pteridines, 2017
Seasonal changes in non-human animals and seasonal affective disorder (SAD) in humans are associated with immune activation in winter relative to summer.
Mohyuddin Hira, Georgiou Polymnia, Wadhawan Abhishek, Daue Melanie L., Brenner Lisa A., Gragnoli Claudia, Saunders Erika F.H., Fuchs Dietmar, Lowry Christopher A., Postolache Teodor T.   +9 more
doaj   +2 more sources

Long-term exposure to particulate air pollution and brachial artery flow-mediated dilation in the Old Order Amish [PDF]

Environmental Health, 2020
Background Atmospheric particulate matter (PM) has been associated with endothelial dysfunction, an early marker of cardiovascular risk. Our aim was to extend this research to a genetically homogenous, geographically stable rural population using ...
Shabnam Salimi, Jeff D. Yanosky, Dina Huang, Jessica Montressor-Lopez, Robert Vogel, Robert M. Reed, Braxton D. Mitchell, Robin C. Puett   +7 more
doaj   +2 more sources

A comparative analysis of the oral microbiome of Amish and non-Amish individuals to strengthen our understanding of variation within the oral microbiome. [PDF]

PLoS ONE
More than 700 phylotypes associated with the oral cavity collectively comprise the oral microbiome. Study of microbiomes has advanced our understanding of human health.
Debra L Wohl, Phillip T Belder, Braxton D Mitchell   +2 more
doaj   +2 more sources

Living the good life? Mortality and hospital utilization patterns in the Old Order Amish. [PDF]

PLoS ONE, 2012
Lifespan increases observed in the United States and elsewhere throughout the developed world, have been attributed in part to improvements in medical care access and technology and to healthier lifestyles.
Braxton D Mitchell, Woei-Jyh Lee, Magdalena I Tolea, Kelsey Shields, Zahra Ashktorab, Laurence S Magder, Kathleen A Ryan, Toni I Pollin, Patrick F McArdle, Alan R Shuldiner, Alejandro A Schäffer   +10 more
doaj   +2 more sources

Evaluation of WISP1 as a candidate gene for bone mineral density in the Old Order Amish [PDF]

Scientific Reports, 2018
Wnt1-inducible signaling pathway protein-1 (WISP1) is a novel target of the Wnt pathway for modulating osteogenesis and improving bone strength. However, it is not clear if genetic variants in the WISP1 region are associated with bone mineral density ...
Xing Wang, Shabnam Salimi, Zhongliang Deng, James Perry, Kathleen A. Ryan, Zhizhen Li, Dongfang Liu, Elizabeth Streeten, Alan R. Shuldiner, Mao Fu   +9 more
doaj   +2 more sources

Gender differences in first and secondhand smoke exposure, spirometric lung function and cardiometabolic health in the old order Amish: A novel population without female smoking. [PDF]

PLoS ONE, 2017
Due to their relatively homogeneous lifestyle and living environment, the Amish offer a novel opportunity to study the health associations of tobacco smoke exposure, particularly secondhand smoke.
Robert M Reed, Mark T Dransfield, Michael Eberlein, Michael Miller, Giora Netzer, Mary Pavlovich, Toni I Pollin, Steven M Scharf, Alan R Shuldiner, Don Sin, Braxton D Mitchell   +10 more
doaj   +2 more sources

Modeled nitrate levels in well water supplies and prevalence of abnormal thyroid conditions among the Old Order Amish in Pennsylvania [PDF]

Environmental Health, 2012
Background Nitrate is a widespread contaminant of drinking water supplies, especially in agricultural areas. Nitrate intake from drinking water and dietary sources can interfere with the uptake of iodide by the thyroid, thus potentially impacting thyroid
Aschebrook-Kilfoy Briseis, Heltshe Sonya L, Nuckols John R, Sabra Mona M, Shuldiner Alan R, Mitchell Braxton D, Airola Matt, Holford Theodore R, Zhang Yawei, Ward Mary H   +9 more
doaj   +2 more sources