Results 51 to 60 of about 11,873,205 (183)

Cross‐ancestry polygenic risk scores enhance Alzheimer's disease risk prediction in multiethnic cohorts

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Genome‐wide association studies (GWAS) have identified 80+ genetic loci associated with Alzheimer's disease (AD), enabling the development of polygenic risk scores (PRS). However, the predictive accuracy of PRS in diverse populations remains low.
Meri Okorie, Caroline Jonson, Alexis P. Oddi, Patricia A. Castruita, Brian Fulton‐Howard, Kristine Yaffe, Jennifer S. Yokoyama, Chinedu Udeh‐Momoh, Shea J. Andrews, for the Alzheimer's Disease Sequencing Project and the Healthy Aging Brain Study—Health Disparities   +9 more
wiley   +1 more source

Stratification by a polygenic risk score of common variation aids in Alzheimer's disease rare variant discovery

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION We utilized an Alzheimer's disease (AD) polygenic risk score (PRS) to discover associations with novel rare variants (RVs). METHODS PRSs for European ancestry (EA) participants of the Alzheimer's Disease Sequencing Project were calculated using summary statistics from a large genome‐wide association study.
Oluwatosin Olayinka, John J. Farrell, Congcong Zhu, Zainab Khurshid, Alzheimer's Disease Sequencing Project, Eden R. Martin, William S. Bush, Margaret A. Pericak‐Vance, Li‐San Wang, Gerard D. Schellenberg, Jonathan L. Haines, Kathryn L. Lunetta, Xiaoling Zhang, Lindsay A. Farrer   +13 more
wiley   +1 more source

Mood Worsening on Days with High Pollen Counts is associated with a Summer Pattern of Seasonality

Pteridines, 2019
Background: Summer/spring-type seasonal affective disorder (S-SAD) is the less common subtype of seasonal affective disorder and evidence regarding potential triggers of S-SAD is scarce. Recent reports support association of airborne-pollen with seasonal
Akram Faisal, Jennings Tyler B., Stiller John W., Lowry Christopher A., Postolache Teodor T.   +4 more
doaj   +1 more source

Of Process, Practice, and Belief: What Can We Learn about Old Amish Church History and Polity from this Special Issue’s Source Documents?

The Journal of Amish and Plain Anabaptist Studies, 2019
A full history of the “Old Amish Church” project (c. 1865 to c. 1955-1973) has yet to be written, at least not in English, and not as an overarching, analytical narrative.
Cory Anderson
doaj  

Genetic Linkage for Bipolar Disorder to the Distal Region of Chromosome 19q: A Large Family Whole Genome Sequencing Study

Bipolar Disorders, Volume 28, Issue 4, June 2026.
ABSTRACT Background Bipolar disorder (BD) is among the most heritable psychiatric disorders, with a genetic architecture likely consisting of both common genetic variants with small effects and rare variants with strong effects in certain families or populations.
Albert H. C. Wong, Andrew D. Paterson, Nicole M. Roslin, Elizabeth Tetzlaff, Andrew B. Sedrak, Young Zhou, Gaurav Sharma, Paul Grof, Anne Duffy   +8 more
wiley   +1 more source

Carrier screening in the reproductive setting—Are there medical implications for the heterozygote?—A guide for clinicians

Pregnancy, Volume 2, Issue 3, May 2026.
Abstract Carrier screening for genetic conditions performed preconception or during pregnancy allows identification of fetal risk for inherited autosomal recessive and X‐linked conditions. The goal is to identify at‐risk patients/couples and offer them reproductive options such as preimplantation genetic diagnosis, prenatal testing, or targeted newborn
Emily B. Rosenfeld, Nicole Kasatkin, Bi Liu Yu, Milen Velinov, Justin S. Brandt, Elena Ashkinadze   +5 more
wiley   +1 more source

Singing of the Old Order Amish in Lancaster County, Pennsylvania [PDF]

, 2014
This dissertation explores the continuity and conformity, as well as changes and diversity of Amish musical life by investigating major rituals, activities, musical genres and repertories of the Lancaster Old Order Amish.
Voelkl, Yuanyuan Sun
core   +1 more source

Constitutive Disorder As Method: A Multilingual Dictionary From Within the Camp

Population, Space and Place, Volume 32, Issue 4, May 2026.
ABSTRACT This article analyzes Multilingual Dictionary – Living Together in a Refugee Camp, a co‐research project documenting words and expressions created, invented, and circulated among migrant communities in the Moria and Mavrovouni camps on Lesvos Island between 2018 and 2022.
Nagehan Uskan
wiley   +1 more source

The Amish Settlement in Honduras, 1968-1978: A (Half) Failed Attempt to Develop an Amish Understanding of Mission

The Journal of Amish and Plain Anabaptist Studies, 2016
For their several-hundred years of successfully maintaining Amish settlements in North America, for what reason would a group of families—largely from Nappanee, IN, and Aylmer, ON—want to start a settlement in Honduras? This account traces the genesis of
Cory Anderson
doaj  

Intracellular protein GBF1 displays significant associations with amyloid pathology in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Despite the identification of familial Alzheimer's disease (FAD) genes and neuropathological alterations, AD displays complex genetic heterogeneity and molecular pathogenesis that warrant further investigation. GBF1 (Golgi brefeldin A resistant guanine nucleotide exchange factor 1) regulates protein trafficking, and genetic ...
Sean J. Miller, Dmitry Prokopenko, Ping Bai, Prasenjit Mondal, Abigael Scott, Wei Zhang, Ashley Gomm, Siyi Zhang, Daniel D. Child, Nolan Shen, Joseph Ward, Scott Schulte, Dan Lei, Brian P. Hafler, Changning Wang, Rudolph E. Tanzi, Can Zhang   +16 more
wiley   +1 more source