Results 261 to 270 of about 2,553,189 (362)

Tryptophan metabolite atlas uncovers organ, age, and sex‐specific variations

FEBS Open Bio, EarlyView.
Tryptophan metabolites were analyzed across twelve organs, the central nervous system, and serum in male and female mice at three life stages. We found tissue‐, sex‐, and age‐specific differences, including increased indole‐3‐pyruvate and kynurenine in aging males.
Lizbeth Perez‐Castro, Afshan F. Nawas, Jessica A. Kilgore, Pedro A. S. Nogueira, M.Carmen Lafita‐Navarro, Paul H. Acosta, Roy Garcia, Noelle S. Williams, Maralice Conacci‐Sorrell   +8 more
wiley   +1 more source

Selective temporary angioembolisation in older adults with pelvic trauma - Two cases. [PDF]

Trauma Case Rep
Gewiess J, Komarek A, Kotelis D, Roshardt J, Ivanova S, Lustenberger T, Bastian JD.   +6 more
europepmc   +1 more source

Indoleamine 2,3‐dioxygenase 1 inhibition reverses cancer‐associated fibroblast‐mediated immunosuppression in high‐grade serous ovarian cancer

FEBS Open Bio, EarlyView.
CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee, Jung Yoon Ho, In Sun Hwang, Youn Jin Choi   +3 more
wiley   +1 more source

Training Health Care Practitioners to Effectively Communicate With Older Adults With Cancer and Their Caregivers. [PDF]

JCO Oncol Pract
Parker PA, Banerjee SC, Alici Y, Nelson CJ, Alexander K, Schofield E, Fasakin FS, Coyle N, Roth AJ, Manna R, Gonzalez J, Ewert R, Korc-Grodzicki B.   +12 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Methods for co-designing health innovations with older adults: A rapid review. [PDF]

Australas J Ageing
Blouin Gagnon L, Turcotte S, DeBroux-Leduc R, Gauthier P, Bier N.   +4 more
europepmc   +1 more source

Physical Fitness and Psychological Benefits of Strength Training in Community Dwelling Older Adults.

, 1997
Toshihiko Tsutsumi, Brian M. Don, Leonard D. Zaichkowsky, Laura Delizonna   +3 more
openalex   +2 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A virtual reality game for older adults' immersive learning. [PDF]

Sci Rep
Cheng L, Pang WYJ, Kong A.
europepmc   +1 more source

Card games are effective tools to enhance foundation year health and safety inductions

FEBS Open Bio, EarlyView.
A series of three card games was developed to actively deliver health and safety education to foundation year students. Most students reported positive responses regarding their enjoyment (89.9 %) and learning (74.7 %) from all games evaluated. Data revealed significant improvements in health and safety knowledge (P < 0.0001).
Rumana Rafiq, Holly Matthews, Daniya Abedalreza, Faten Yahya, Matthew Allan Jones   +4 more
wiley   +1 more source