Results 321 to 330 of about 11,669,963 (401)

Exploring Functionally Enhanced BLP‐Trained Macrophage Subpopulations in S. Aureus Infection: Underlying Mechanisms and Therapeutic Significance

open access: yesAdvanced Science, EarlyView.
BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan   +13 more
wiley   +1 more source

Okanin Suppresses the Growth of Colorectal Cancer Cells by Targeting at Peroxiredoxin 5

open access: yesAdvanced Science, EarlyView.
Okanin suppresses colorectal cancer growth by directly targeting PRDX5. This natural compound selectively binds peroxiredoxin 5 (PRDX5), inhibiting its activity and inducing WSB1‐mediated degradation. PRDX5 loss elevates ROS, suppresses GPX4 via SIAH2, and further triggers cell death (apoptosis and ferroptosis).
Ji Zhong Zhao   +9 more
wiley   +1 more source

Effects of HIIT at different frequencies in an aquatic environment on mental health in multimorbid older people: A randomized clinical trial. [PDF]

open access: yesClinics (Sao Paulo)
da Silva VOS   +9 more
europepmc   +1 more source

Technology-Assisted Physical Activity Interventions for Older People in Their Home-Based Environment: Scoping Review. [PDF]

open access: yesJMIR Aging
Dubbeldam R   +27 more
europepmc   +1 more source

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