Results 91 to 100 of about 7,346,872 (254)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Optimising Retail Environments for Older Adults: Insights into Customer Behaviour and Organisational Performance

open access: yesAdministrative Sciences
Retailers have traditionally prioritised younger customers, often overlooking the distinct needs of older consumers. As this demographic grows, it is increasingly important to cater to their shopping preferences. This study explores the behaviours, needs,
Ljerka Sedlan König
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Prevalence of hypertension and related risk factors in older Chinese population: a meta-analysis

open access: yesFrontiers in Public Health
ObjectiveHypertension is the most challenging public health problem worldwide and seriously affects human health. To date, there are no epidemiological studies on the prevalence of and risk factors for hypertension among older people in mainland China ...
Zicheng Wang   +4 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Warfarin Adherence and Its Associated Factors in Thai Older Adults with Atrial Fibrillation

open access: yesJournal of Multidisciplinary Healthcare
Autchariya Poungkaew,1 Thitipong Tankumpuan,2 Chontira Riangkam,1 Junporn Kongwatcharapong,3 Tassanee Daekunthod,4 Khachol Sriyayang,4 Rungroj Krittayaphong,5 Binu Koirala6 1Department of Medical Nursing, Faculty of Nursing, Mahidol University, Bangkok ...
Poungkaew A   +7 more
doaj  

Bayesian Approach to Stochastic Estimation of Population Survival Curves in Chile Using ABC Techniques and Its Impact over Social Structures

open access: yesComputation
In Chile and worldwide, life expectancy has consistently increased over the past six decades. Thus, the purpose of this study was to identify, measure, and estimate the population mortality ratios in Chile, mortality estimates are used to calculate life ...
Rolando Rubilar-Torrealba   +3 more
doaj   +1 more source

Hospitalised injuries in older Australians: 2011-12 [PDF]

open access: yes, 2014
This report examines the most frequent causes of hospitalisations due to injury sustained by Australians, aged 65 years or older, during the period 1 July 2011 to 30 June 2012.

core  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Ageing in Place, Healthy Ageing: Local Community Involvement in the Prevention Approach to Eldercare

open access: yesSocial Inclusion
The increase in ageing societies is posing new and urgent societal and political challenges to meeting people’s medical, personal, and social needs in old age.
Chiara Lodi Rizzini   +2 more
doaj   +1 more source

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