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Pharmacology of oleanolic acid and ursolic acid
Journal of Ethnopharmacology, 1995Oleanolic acid and ursolic acid are triterpenoid compounds that exist widely in food, medicinal herbs and other plants. This review summarizes the pharmacological studies on these two triterpenoids. Both oleanolic acid and ursolic acid are effective in protecting against chemically induced liver injury in laboratory animals.
Jie Liu
exaly +3 more sources
Oleanolic acid and ursolic acid: Research perspectives
Journal of Ethnopharmacology, 2005Oleanolic acid and ursolic acid are ubiquitous triterpenoids in plant kingdom, medicinal herbs, and are integral part of the human diet. During the last decade over 700 research articles have been published on their research, reflecting tremendous interest and progress in our understanding of these triterpenoids.
Jie Liu
exaly +3 more sources
Oleanolic Acid in Lardizabala biternata
Journal of Pharmaceutical Sciences, 1961Oleanolic acid was isolated and identified as a sapogenin of a glycosidic fraction from Lardizabala biternata. By means of an alcoholic extraction of the dried and pulverized plant an extract was obtained which yielded a water-soluble glycosidic fraction. Acid hydrolysis of this material gave oleanolic acid which was purified and identified.
M, SILVA, P, MANCINELLI
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Oleanolic Acid from Cranberries*
Journal of the American Pharmaceutical Association (Scientific ed.), 1953A modified procedure, involvin decolorization of the ammonium salt, is feescribed for the purification of crude ursolic acid obtained from cranberries. Oleanolic acid was isolated from the mother liquors remaining from the final recrystallization of the purified product.
B Y, WU, L M, PARKS
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Acta Crystallographica Section C Crystal Structure Communications, 1997
The title compound, 3-[(2-carboxyethyl)carbonyloxy]-olean-12-en-28-oic acid, C34H5206, was synthesized as a derivative of oleanolic acid in order to improve its solubility and bioavailability. It has been used as an anti-inflammatory and antihepatitis drug in east Asia.
J. Yang, J. W. Quail, Z. Jia
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The title compound, 3-[(2-carboxyethyl)carbonyloxy]-olean-12-en-28-oic acid, C34H5206, was synthesized as a derivative of oleanolic acid in order to improve its solubility and bioavailability. It has been used as an anti-inflammatory and antihepatitis drug in east Asia.
J. Yang, J. W. Quail, Z. Jia
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Solubilization of oleanolic acid and ursolic acid by cosolvency
Archives of Pharmacal Research, 1997Solubilities of oleanolic acid and ursolic acid in aqueous surfactant solutions, liquid polyethylene glycols (PEG), and solvents of various polarity were measured. The results showed that the solutes were slightly or moderately solubilized in the surfactant solutions and the liquid PEGs.
I J, Jin, Y I, Ko, Y M, Kim, S K, Han
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Oleanolic acid and ursolic acid stabilize liposomal membranes
Lipids, 1997AbstractThe effects of oleanolic acid (OA) and ursolic acid (UA) on the fluidity and stability of dipalmitoyl phosphatidylcholine (DPPC) liposomal membrane were monitored by measuring the fluorescence polarization of 1,6‐diphenyl‐1,3,5‐hexatriene labeled in the liposomal membrane and the leakage of calcein from the probe‐encapsulated liposomes.
S K, Han +4 more
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J. Chem. Soc. C, 1970
β-Amyrin has been converted into 3β-acetoxy-13-hydroxyoleanane. Photolysis of the nitrite of this alcohol and further standard transformations gave oleanolic acid lactone acetate and thence oleanolic acid. This conversion of β-amyrin into oleanolic acid represents, in the formal sense, a total synthesis of the latter.By a similar series of reactions ...
R. B. Boar +3 more
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β-Amyrin has been converted into 3β-acetoxy-13-hydroxyoleanane. Photolysis of the nitrite of this alcohol and further standard transformations gave oleanolic acid lactone acetate and thence oleanolic acid. This conversion of β-amyrin into oleanolic acid represents, in the formal sense, a total synthesis of the latter.By a similar series of reactions ...
R. B. Boar +3 more
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Synthesis of glycosides of oleanolic acid
Bulletin of the Academy of Sciences, USSR Division of Chemical Science, 19661. The synthesis of glycosides of oleanolic acid has been carried out. 2. On the basis of the synthesis of the glucoside of oleanolic acid, the possibility of using sugar orthoesters for the selective glycosylation of the alcoholic hydroxy group of a hydroxy acid containing an unprotected carboxyl has been shown.
N. K. Kochetkov +3 more
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Die Pharmazie, 2009
The aim of this study was to develop and validate a simple HPLC method for the quantitative determination of the oleanolic acid (OA) content and partition coefficient of OA in a submicron emulsion-based formulation (SE-OA). A DiamonsilTM C18 (150 mm × 4.6 mm, 5 μm) column was eluted with a mobile phase consisting of methanol/water (95 : 5, v/v).
Yong-Xing Zhao, Yong-Xing Zhao +2 more
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The aim of this study was to develop and validate a simple HPLC method for the quantitative determination of the oleanolic acid (OA) content and partition coefficient of OA in a submicron emulsion-based formulation (SE-OA). A DiamonsilTM C18 (150 mm × 4.6 mm, 5 μm) column was eluted with a mobile phase consisting of methanol/water (95 : 5, v/v).
Yong-Xing Zhao, Yong-Xing Zhao +2 more
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