Results 131 to 140 of about 2,903,157 (267)
The dark sides of the GPCR tree ‐ research progress on understudied GPCRs
British Journal of Pharmacology, Volume 182, Issue 14, Page 3109-3134, July 2025.Abstract A large portion of the human GPCRome is still in the dark and understudied, consisting even of entire subfamilies of GPCRs such as odorant receptors, class A and C orphans, adhesion GPCRs, Frizzleds and taste receptors. However, it is undeniable that these GPCRs bring an untapped therapeutic potential that should be explored further.
Magdalena M. Scharf +10 more
wiley +1 more source
Olfaction in Neurologic and Neurodegenerative Diseases: A Literature Review
International Archives of Otorhinolaryngology, 2015 Introduction Loss of smell is involved in various neurologic and neurodegenerative diseases, such as Parkinson disease and Alzheimer disease. However, the olfactory test is usually neglected by physicians at large.
Maria Dantas Costa Lima Godoy +4 more
doaj +1 more source
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, Volume 182, Issue 14, Page 3178-3210, July 2025.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
A bio. tools collection of online resources for GPCR research
British Journal of Pharmacology, Volume 182, Issue 14, Page 3301-3319, July 2025.G protein‐coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options.
Tõnis Laasfeld +9 more
wiley +1 more source
Psychogeriatrics, Volume 25, Issue 4, July 2025.Abstract Background The use of a variety of sensory elements is recommended when implementing reminiscence therapy. However, there is a lack of evidence supporting this recommendation. This study aimed to examine the benefits of using smell as a memory trigger during reminiscence therapy for community‐dwelling older adults, focusing on its effects on ...
Hideaki Hanaoka +12 more
wiley +1 more source
Olfaction-associated quality of life: Polish adaptation and validation of a Questionnaire of Olfactory Disorders (QOD-PL) in patients with chronic rhinosinusitis [PDF]
, 2023 Katarzyna Resler +6 more
openalex +1 more source
Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications
Advanced Science, Volume 12, Issue 21, June 5, 2025.HDAC6 regulates primary cilia, crucial for cellular signalling and environmental responses. Dysregulation of HDAC6 contributes to ciliopathies, affecting multiple organs. This review examines HDAC6's role in ciliogenesis, its interaction with signaling molecules, and its potential as a therapeutic target.
Zhiyi Wang +5 more
wiley +1 more source
The Laryngoscope, Volume 135, Issue 6, Page 2089-2096, June 2025.Olfactory training (OT) significantly improves olfactory function in patients with post‐viral olfactory dysfunction compared to healthy controls. OT was associated with enhanced functional activation in the orbitofrontal cortex and parahippocampal region.
Zetian Li +8 more
wiley +1 more source
Réduction de la nuisance olfactive par oxydation photocatalytique [PDF]
S\'eminaire 2007 de l'Ecole Doctorale RP2E "Ing\'enierie des
Ressources, Proc\'ed\'es, Produits et Environnement", Nancy : France (2007), 2009 Heterogeneous photocatalysis is an interesting alternative for the purification, decontamination and smell abatment of air. In the present work, the photocatalytic oxidation of 2-butanone (MEK : methyl ethyle ketone) is investigated, this low molecular mass product being the source of serious smell pollution. The influence of light and of the pollutant
arxiv
In Situ Gels for Nasal Delivery: Formulation, Characterization and Applications
Macromolecular Materials and Engineering, Volume 310, Issue 6, June 2025.Drug delivery through the nasal route offers many advantages, but is hampered by a number of challenges, such as the short drug retention time caused by mucociliary clearance. In situ forming gels, which undergo a sol‐to‐gel transition with specific triggers at the site of action, present real opportunities in this field.
Li Qian +2 more
wiley +1 more source