Results 71 to 80 of about 54,454 (186)

HOF•CH₃CN—The Most Potent Oxygen Transfer Agent for a Large Variety of Organic Molecules

Molecules
The complex of hypofluorous acid with acetonitrile—HOF•CH3CN—is the only substance possessing a truly electrophilic oxygen. This fact makes it the only tool suitable for transferring oxygen atoms to sites that are not accessible to this vital element. We
Shlomo Rozen
doaj   +1 more source

Apatite in Carbonatite Preserving Primary Magmatic, Post‐Magmatic Overgrowth, and Post India‐Asia Collision‐Related Hydrothermal Alteration: Evidenced From U–Pb Isotope and Trace Element Geochemistry

Geological Journal, EarlyView.
U–Pb isotope and trace element geochemistry of apatite from carbonatites of Peshawar Plain Alkaline Igneous Province, western Himalaya shows Permo‐Carboniferous magmatism, an additional magmatic pulse during Cretaceous, and post‐magmatic hydrothermal/metasomatism during Oligocene. ABSTRACT U–Pb isotope and trace element geochemistry of apatite combined
Mehboob ur Rashid, Hafiz U. Rehman, Hao‐Yang Lee, Sun‐Lin Chung, Kaushik Das, Kazumasa Aoki, Muhammad Jawad Zeb, Nasir Ahmad, Muhammad Hussain, Hiroshi Yamamoto   +9 more
wiley   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Conjugation‐Length Dependent Interplay Between Charge Transfer and Locally Excited States in Sequence‐Defined Donor–Acceptor Substituted Oligo(Phenylene Ethynylene)s

Macromolecular Rapid Communications, EarlyView.
Iterative synthesis gives access to sequence‐defined oligo(para‐phenylene ethynylene)s, bridging donor and acceptor units through stepwise extension of the conjugated backbone. Accurate length control enables systematic structure‐property relationship investigations across absorption, emission, and excited‐state dynamics.
Qianyu Cai, Till Paha, Marianne Armbruster, André Jung, Eli Zysman‐Colman, Andreas‐Neil Unterreiner, Michael A. R. Meier   +6 more
wiley   +1 more source

Protecting CEACAM1 Expression Prevents Diet‐Induced Metabolic Dysfunction and Hepatic Fibrosis in Male Mice

Obesity, EarlyView.
ABSTRACT Objective High‐fat diet represses Ceacam1 transcription via a PPARα‐mediated mechanism to cause insulin resistance before inflammation develops. The current study investigated whether mutating PPRE‐RXRα in Ceacam1 promoter prevents diet‐induced metabolic abnormalities and hepatic fibrosis in male C57BL6/J mice.
Raziyeh Abdolahipour, Saja S. Khuder, William M. Philbrick, Agnes O. Portuphy, Getachew D. Belew, Hatem G. Fallouh, Harrison T. Muturi, Boyeon Kim, Jason K. Kim, Sonia M. Najjar   +9 more
wiley   +1 more source

Chiral Bifacial Indacenodithiophene‐Based Hole‐Transport Materials With Chirality‐Induced Spin Selectivity: Chirality‐Spin Polarity Correspondence and Perovskite Passivation

Small, EarlyView.
Homochiral bifacial indacenodithiophene (IDT)‐based hole‐transport materials form amorphous spin‐coated films showing pronounced chirality‐induced spin selectivity (CISS) with spin polarization ≈ 60%, and reveal a robust chirality–spin‐polarity correspondence.
Shuang Li, Fumitaka Ishiwari, Ryosuke Nishikubo, Akinori Saeki   +3 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, EarlyView.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, EarlyView.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source