Results 1 to 10 of about 11,803 (82)

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice

Brain, Behavior, and Immunity, 2017
It is increasingly recognized that sleep disturbances and Alzheimer's disease (AD) share a bidirectional relationship. AD patients exhibit sleep problems and alterations in the regulation of circadian rhythms; conversely, poor quality of sleep increases the risk of development of AD.
Grasielle C, Kincheski, Isabela S, Valentim, Julia R, Clarke, Danielle, Cozachenco, Morgana T L, Castelo-Branco, Angela M, Ramos-Lobo, Vivian M B D, Rumjanek, José, Donato, Fernanda G, De Felice, Sergio T, Ferreira   +9 more
openaire   +3 more sources

Distinct oligomeric assemblies of STING induced by non-nucleotide agonists [PDF]

Nature Communications
STING plays essential roles coordinating innate immune responses to processes that range from pathogenic infection to genomic instability. Its adaptor function is activated by cyclic dinucleotide (CDN) secondary messengers originating from self (2’3 ...
Anant Gharpure, Ariana Sulpizio, Johannes R. Loeffler, Monica L. Fernández-Quintero, Andy S. Tran, Luke L. Lairson, Andrew B. Ward   +6 more
doaj   +2 more sources

Taxifolin: A Potential Therapeutic Agent for Cerebral Amyloid Angiopathy

Frontiers in Pharmacology, 2021
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of β-amyloid (Aβ) in the walls of cerebral vessels, leading to complications such as intracerebral hemorrhage, convexity subarachnoid hemorrhage and cerebral microinfarcts.
Satoshi Saito, Satoshi Saito, Masashi Tanaka, Masashi Tanaka, Noriko Satoh-Asahara, Roxana Octavia Carare, Masafumi Ihara   +6 more
doaj   +1 more source

Probing the run-on oligomer of activated SgrAI bound to DNA. [PDF]

PLoS ONE, 2015
SgrAI is a type II restriction endonuclease with an unusual mechanism of activation involving run-on oligomerization. The run-on oligomer is formed from complexes of SgrAI bound to DNA containing its 8 bp primary recognition sequence (uncleaved or ...
Santosh Shah, Jonathan Sanchez, Andrew Stewart, Michael M Piperakis, Richard Cosstick, Claire Nichols, Chad K Park, Xin Ma, Vicki Wysocki, Jurate Bitinaite, Nancy C Horton   +10 more
doaj   +1 more source

Cryptic Nature of a Conserved, CD4-Inducible V3 Loop Neutralization Epitope in the Native Envelope Glycoprotein Oligomer of CCR5-Restricted, but Not CXCR4-Using, Primary Human Immunodeficiency Virus Type 1 Strains [PDF]

Journal of Virology, 2005
ABSTRACT The external subunit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env), gp120, contains conserved regions that mediate sequential interactions with two cellular receptor molecules, CD4 and a chemokine receptor, most commonly CCR5 or CXCR4.
LUSSO, PAOLO, EARL PL, SIRONI F, SANTORO F, RIPAMONTI C, SCARLATTI G, LONGHI R, BERGER EA, BURASTERO SE   +8 more
openaire   +5 more sources

A quantitative real-time PCR method for absolute telomere length

BioTechniques, 2008
Telomere shortening is an important risk factor for cancer and accelerated aging. Here we describe the development of a simple and reproducible method to measure absolute telomere length. Based on Cawthon's quantitative real-time PCR (qRT-PCR) assay, our
Nathan J. O'Callaghan, Varinderpal S. Dhillon, Philip Thomas, Michael Fenech   +3 more
doaj   +1 more source

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Alzheimer’s Research & Therapy, 2019
Background Synaptic damage precedes neuron death in Alzheimer’s disease (AD). Neurexins, NRXN1, NRXN2, and NRXN3, are presynaptic adhesion molecules that specify neuron synapses and regulate neurotransmitter release.
Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan, Qing-Rong Liu   +5 more
doaj   +1 more source

Safety assessment of the substance poly((R)‐3‐hydroxybutyrate‐co‐(R)‐3‐hydroxyhexanoate) for use in food contact materials

EFSA Journal, 2019
The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP Panel) assessed the safety of poly((R)‐3‐hydroxybutyrate‐co‐(R)‐3‐hydroxyhexanoate) (PHBH), CAS No 147398‐31‐0 and food contact material (FCM) substance No 1059.
EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP), Vittorio Silano, José Manuel Barat Baviera, Claudia Bolognesi, Beat Johannes Brüschweiler, Andrew Chesson, Pier Sandro Cocconcelli, Riccardo Crebelli, David Michael Gott, Konrad Grob, Evgenia Lampi, Alicja Mortensen, Inger‐Lise Steffensen, Christina Tlustos, Henk Van Loveren, Laurence Vernis, Holger Zorn, Laurence Castle, Jean‐Pierre Cravedi, Roland Franz, Martine Kolf‐Clauw, Maria Rosaria Milana, Karla Pfaff, Kettil Svensson, Maria de Fatima Tavares Poças, Detlef Wölfle, Katharina Volk, Gilles Rivière   +27 more
doaj   +1 more source

Tankyrase-1-mediated PARsylation directs TFEB partner switching to regulate selective Wnt target gene expression. [PDF]

Mol Cells
Song G, Park C, Jho EH.
europepmc   +1 more source

Enzymatic Synthesis of an Undecorated Capsular Polysaccharide from <i>Campylobacter jejuni</i>. [PDF]

Biochemistry
Xiang DF, Narindoshvili T, Raushel FM.
europepmc   +1 more source