Results 1 to 10 of about 25,062 (219)

Distinct oligomeric assemblies of STING induced by non-nucleotide agonists [PDF]

Nature Communications
STING plays essential roles coordinating innate immune responses to processes that range from pathogenic infection to genomic instability. Its adaptor function is activated by cyclic dinucleotide (CDN) secondary messengers originating from self (2’3 ...
Anant Gharpure, Ariana Sulpizio, Johannes R. Loeffler, Monica L. Fernández-Quintero, Andy S. Tran, Luke L. Lairson, Andrew B. Ward   +6 more
doaj   +2 more sources

Taxifolin: A Potential Therapeutic Agent for Cerebral Amyloid Angiopathy

Frontiers in Pharmacology, 2021
Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of β-amyloid (Aβ) in the walls of cerebral vessels, leading to complications such as intracerebral hemorrhage, convexity subarachnoid hemorrhage and cerebral microinfarcts.
Satoshi Saito, Satoshi Saito, Masashi Tanaka, Masashi Tanaka, Noriko Satoh-Asahara, Roxana Octavia Carare, Masafumi Ihara   +6 more
doaj   +1 more source

Probing the run-on oligomer of activated SgrAI bound to DNA. [PDF]

PLoS ONE, 2015
SgrAI is a type II restriction endonuclease with an unusual mechanism of activation involving run-on oligomerization. The run-on oligomer is formed from complexes of SgrAI bound to DNA containing its 8 bp primary recognition sequence (uncleaved or ...
Santosh Shah, Jonathan Sanchez, Andrew Stewart, Michael M Piperakis, Richard Cosstick, Claire Nichols, Chad K Park, Xin Ma, Vicki Wysocki, Jurate Bitinaite, Nancy C Horton   +10 more
doaj   +1 more source

Cryptic Nature of a Conserved, CD4-Inducible V3 Loop Neutralization Epitope in the Native Envelope Glycoprotein Oligomer of CCR5-Restricted, but Not CXCR4-Using, Primary Human Immunodeficiency Virus Type 1 Strains [PDF]

Journal of Virology, 2005
ABSTRACT The external subunit of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env), gp120, contains conserved regions that mediate sequential interactions with two cellular receptor molecules, CD4 and a chemokine receptor, most commonly CCR5 or CXCR4.
LUSSO, PAOLO, EARL PL, SIRONI F, SANTORO F, RIPAMONTI C, SCARLATTI G, LONGHI R, BERGER EA, BURASTERO SE   +8 more
openaire   +6 more sources

A Phasin with Many Faces: Structural Insights on PhaP from Azotobacter sp. FA8 [PDF]

, 2014
Phasins are a group of proteins associated to granules of polyhydroxyalkanoates (PHAs). Apart from their structural role as part of the PHA granule cover, different structural and regulatory functions have been found associated to many of them, and ...
Bucci, Hernán Andrés, Catone, Mariela Verónica, Di Paola, Matías Ezequiel, Mezzina, Mariela Paula, Pettinari, María Julia, Wetzler, Diana Elena   +5 more
core   +4 more sources

A quantitative real-time PCR method for absolute telomere length

BioTechniques, 2008
Telomere shortening is an important risk factor for cancer and accelerated aging. Here we describe the development of a simple and reproducible method to measure absolute telomere length. Based on Cawthon's quantitative real-time PCR (qRT-PCR) assay, our
Nathan J. O'Callaghan, Varinderpal S. Dhillon, Philip Thomas, Michael Fenech   +3 more
doaj   +1 more source

A high throughput molecular force assay for protein-DNA interactions. [PDF]

, 2011
An accurate and genome-wide characterization of protein–DNA interactions such as transcription factor binding is of utmost importance for modern biology. Powerful screening methods emerged.
Albrecht, Albrecht, Bartels, Berger, Bizzarri, Blank, Bulyk, Bustamante, Bustamante, Cao, Dominik Ho, Dose, Evans, Gittes, Harbison, Hermann E. Gaub, Ho, Ho, Iyer, Jeltsch, Jen-Jacobson, Koch, Koch, Kuhner, Lee, Lesser, Maerkl, Merkel, Morfill, Moy, Mukherjee, Philip M. D. Severin, Pincet, Ren, Rief, Segal, Sidorova, Sidorova, Strunz, Uhrig, Viani, Wiegand, Wu   +42 more
core   +1 more source

The HLA-E Gene encodes two differentially regulated Transcripts and a Cell Surface Protein [PDF]

, 1992
An HLA-E-specific oligonucleotide probe was used to study the expressioonf HLA-E. This probed etects two HLA-E transcripts, 1.8 and 2.7 kb in size, which are present in varying ratios in allt issues and cell lines investigated.
Honka, Thomas, Johnson, Judith P., Person, Susanne, Ulbrecht, Matthias, Weiss, Elisabeth H.   +4 more
core   +1 more source

Methionine 129 variant of human prion protein oligomerizes more rapidly than the valine 129 variant - Implications for disease susceptibility to Creutzfeldt-Jakob disease [PDF]

, 2004
The human PrP gene (PRNP) has two common alleles that encode either methionine or valine at codon 129. This polymorphism modulates disease susceptibility and phenotype of human transmissible spongiform encyphalopathies, but the molecular mechanism by ...
Abdessamad Tahiri-Alaoui, Andrew C. Gill, Petra Disterer, William James, Prusiner, Weissmann, Will, Bruce, Hill, Prusiner, Prusiner, Collinge, Windl, Palmer, Brown, Baker, Cervenakova, Parchi, Hill, Collinge, Hauw, Goldfarb, Goldfarb, Dlouhy, Dermaut, Croes, Liemann, Riek, Alonso, Baskakov, Jackson, Baskakov, Gill, Lu, Lu, Landon, Safar, Bessen, Zahn, Riek, Nguyen, Tahiri-Alaoui, Santini, Wong, Wildegger, Matouschek, Vendruscolo, Kim, Fasman, Baskakov, Qin, Oesch, Conway, Sayer, Rhie, Schatzl, Mead   +56 more
core   +1 more source

Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer’s disease

Alzheimer’s Research & Therapy, 2019
Background Synaptic damage precedes neuron death in Alzheimer’s disease (AD). Neurexins, NRXN1, NRXN2, and NRXN3, are presynaptic adhesion molecules that specify neuron synapses and regulate neurotransmitter release.
Akitoyo Hishimoto, Olga Pletnikova, Doyle Lu Lang, Juan C. Troncoso, Josephine M. Egan, Qing-Rong Liu   +5 more
doaj   +1 more source