Results 131 to 140 of about 26,087 (219)

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

Advanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin, Jiale Sun, Yuqing Mao, Yuhao Tang, Fuan Wang, Zhihong Liu, Jing Wang   +6 more
wiley   +1 more source

Synthesis and Characterization of Fully Bio-Based Butylene Succinate Oligomers with Varying Molecular Weights for Sustainable Food Packaging Applications. [PDF]

Polymers (Basel)
Olivas-Alonso C, Flores Y, Martínez de Ilarduya A, Chiralt A, Torres-Giner S.   +4 more
europepmc   +1 more source

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Pt-seq unveils the genomic binding pattern of platinum-based drugs. [PDF]

Sci Adv
Shao C, Li M, Liu L, Bai D, Yang J, Liu C, Cai L, Wang X, Peng J, Guo Z, Yi C.   +10 more
europepmc   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Learning the sequence code of protein expression in human immune cells. [PDF]

Sci Adv
Nicolet BP, Jurgens AP, Bresser K, Bradarić A, Guislain A, Wolkers MC.   +5 more
europepmc   +1 more source

Bridging Green Chemistry and Circular Economy: A Pathway to Sustainable Polyester Plastics Through Feedstock, Synthesis, and Waste Upcycling

Advanced Science, EarlyView.
This review summarizes green and low‐carbon strategies throughout the entire life cycle of polyester plastics, including sustainable monomer synthesis, optimization polymerization, efficient recycling, and advanced upcycling technologies. The synergistic implementation of these strategies is expected to significantly promote the development of a ...
Jinzhou Li, Junliang Chen, Yingbing Zhang, Li Wang, Pin Gao, Jianping Yang   +5 more
wiley   +1 more source

Genome organization by SATB1 binding to base-unpairing regions (BURs) provides a scaffold for SATB1-regulated gene expression. [PDF]

Elife
Kohwi Y, Wong X, Grange M, Sexton T, Richards HW, Kitagawa Y, Sakaguchi S, Liang YC, Chuong CM, Botchkarev VA, Taniuchi I, Reddy KL, Kohwi-Shigematsu T.   +12 more
europepmc   +1 more source

Enhancing Chemical Stability and Molecular Selectivity of Porous Organic Cages via Core–Shell Polymer Coating

Advanced Science, EarlyView.
This study presents an interfacial method to fabricate POC@polymer core–shell nanostructures combining cage porosity with polymer robustness. Through chiral self‐assembly and non‐solvent‐induced surface polymerisation, uniform ∼20 nm polymer‐coated particles are produced.
Danyu Li, Yanling Huang, Huiyu Liu, Yuzhen Wen, Dongxu Wang, Tao Li, Shan Jiang   +6 more
wiley   +1 more source

A dynamical systems model for the total fission rate in Drp1-dependent mitochondrial fission. [PDF]

PLoS Comput Biol
Leinheiser AK, Mitchell CC, Rooke E, Strack S, Grueter CE.   +4 more
europepmc   +1 more source