Results 161 to 170 of about 25,062 (219)

Hypoxia‐Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis

Advanced Science, EarlyView.
Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou, Shuying Qiu, Xia Yang, Yan Wu, Xinxia Yao, Hangqi Hu, Jingfeng Luo, Chandra Sugiarto Wijaya, Lingfeng Ma, Xiaojun Long, Lingna Xu, Jinquan Liu, Chaoqun Wang, Yibin Pan, Xiaona Chen, Hongchuan Jin, Xian Wang   +16 more
wiley   +1 more source

CD8⁺ T cell targeting of tumor antigens presented by HLA-E. [PDF]

Sci Adv
Iyer RF, Verweij MC, Nair SS, Morrow D, Mansouri M, Chakravarty D, Beechwood T, Meyer C, Uebelhoer L, Lauron EJ, Selseth A, John N, Thin TH, Dzedzik S, Havenar-Daughton C, Axthelm MK, Douglas J, Korman A, Bhardwaj N, Tewari AK, Hansen S, Malouli D, Picker LJ, Früh K.   +23 more
europepmc   +1 more source

Synthesis of Diaryl‐ and Dialkynylphosphinates From Ubiquitous PV Sources via a Redox‐Neutral Approach

Advanced Science, EarlyView.
Classical strategies for P─C bond formation rely on precursors (e.g., PH3, H2PO2, PCl3) obtained from P4, which is produced via the energy‐intensive thermal process. Here, an alternative, redox‐neutral approach is explored. Primary phosphate sources are activated with triflic anhydride (Tf2O) and 4‐dimethylaminopyridine (DMAP) to a versatile PV ...
Tobias Schneider, Kai Schwedtmann, Jannis Fidelius, Rosa M. Gomila, Antonio Frontera, Jan J. Weigand   +5 more
wiley   +1 more source

Correlation of p53 oligomeric status and its subcellular localization in the presence of the AML-associated NPM mutant. [PDF]

PLoS One
Holoubek A, Strachotová D, Wolfová K, Otevřelova P, Belejová S, Röselová P, Benda A, Brodská B, Herman P.   +8 more
europepmc   +1 more source

The Evolution of Functional Amyloids and Their Impact on Host–Microbe Interactions

Advanced Science, EarlyView.
This review describes functional amyloids and highlights the importance of structural repetition and molecular mimicry that distinguish the amyloid fold. The authors describe how amyloid can be the last universal common ancestor of protein folds. The authors also discuss how microbes utilize functional amyloids and how the structural characteristics of
Divya Kolli, Saroj K. Rout, Roland Riek, Matthew R. Chapman   +3 more
wiley   +1 more source

Heterozygous and generalist MxA super-restrictors overcome breadth-specificity trade-offs in antiviral restriction. [PDF]

Sci Adv
Geiger RA, Khera D, Tenthorey JL, Kochs G, Graf L, Emerman M, Malik HS.   +6 more
europepmc   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

An Overview of Glutaminyl Cyclase as a Promising Drug Target for Alzheimer's Disease. [PDF]

Biomedicines
Madhusudhana R, Boyle E, Cen Y.
europepmc   +1 more source

Why Will Polymers Win the Race for Solid‐State Batteries?

Advanced Science, EarlyView.
Polymer‐based electrolytes are leading solid‐state battery contenders by balancing processability, mechanical compliance, and interfacial compatibility. Their tunable chemistry enables scalable, cost‐effective manufacturing, overcoming oxide/sulfide limitations.
Zhiyong Li, Sisi Peng, Lu Wei, Xin Guo
wiley   +1 more source

Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida. [PDF]

Nat Microbiol
de Witt J, Luthe T, Wiechert J, Jensen K, Polen T, Wirtz A, Thies S, Frunzke J, Wynands B, Wierckx N.   +9 more
europepmc   +1 more source