Results 161 to 170 of about 26,016 (217)

End-to-End Backbone Cyclization Enhances Passive Permeability of bRo5 Oligomeric Depsipeptides with Nonlinear Size Dependence. [PDF]

ACS Med Chem Lett
Thorpe MP, Hopkins CR, Johnston JN.
europepmc   +1 more source

Implantable Drug Delivery Systems for Skeletal Muscles and Eyes

Advanced NanoBiomed Research, EarlyView.
This review highlights the different types of recent implantable drug delivery systems (IDDS) fabricated for a use with skeletal muscles, and with eyes. It presents the developments already made and the current research directions, showing the evolution of IDDS and their great diversity.
Serge Ostrovidov, Murugan Ramalingam, Hongkai Wu, Toshinori Fujie, Yukinari Nakamura, Takeshi Hori, Yuji Nashimoto, Xuetao Shi, Hirokazu Kaji   +8 more
wiley   +1 more source

Surface Avidity of Anionic Polypeptide Coatings on Layer‐by‐Layer Nanoparticles Target Cancer‐Associated Amino Acid Transporters

Angewandte Chemie, EarlyView.
Electrostatically layered nanoparticles (NPs) coated with anionic polypeptides selectively target cancer cells by engaging amino acid transporters. Poly(L‐glutamate) (PLE) coatings cluster the glutamine transporter SLC1A5, prolonging NP surface retention, while poly(L‐aspartate) (PLD) coatings also bind SLC1A3, potentially promoting faster ...
Ivan S. Pires, Margaret M. Billingsley, Ezra Gordon, Andrew J. Pickering, Eva Cai, Gonzalo J. Esparza, Mae L. Pryor, Alexander D. Stoneman, Aidan Kindopp, Darrell J. Irvine, Paula T. Hammond   +10 more
wiley   +2 more sources

Stabilized D₂R G protein-coupled receptor oligomers identify multi-state β-arrestin complexes. [PDF]

Nat Commun
Sharrocks KL, Fanelli F, Liu Y, Milner AJ, Yining W, Byrne B, Hanyaloglu AC.   +6 more
europepmc   +1 more source

3D Hydrogel Cell Cultures and Their Biomedical Applications

Advanced NanoBiomed Research, EarlyView.
The review highlights the advantages of hydrogel‐based 3D cell cultures over traditional 2D models. These hydrogels closely mimic natural cellular environments, improving research in tissue engineering, drug discovery, cancer studies, and neuroscience.
Tri Lan Thai, Arushi Manchanda, Sarah L. Higginbottom, Estrella Sanz Rodriguez, Richard Wilson, Eva Tomaskovic‐Crook, Jeremy M. Crook, Brett Paull   +7 more
wiley   +1 more source

Fibril Structure of Desiccation‐Protective Tardigrade Protein CAHS‐8

Angewandte Chemie, EarlyView.
We present the atomic structure of the fibril formed by an intrinsically disordered protein that has been shown to be responsible for remarkable environmental stress in tardigrades. X‐ray crystallography reveals a unique mechanism of fibril assembly whereby a single helix forms a stable, antiparallel coiled‐coil dimer, which then assembles into a ...
Anas Malki, Jean‐Marie Teulon, Emmi A. Mikkola, Damien Maurin, Jean‐Luc Pellequer, Max H. Nanao, Martin Blackledge   +6 more
wiley   +2 more sources

Controlled Formation of DNA Condensates as Model Nuclei in Monodisperse Giant Vesicles. [PDF]

JACS Au
Yoneyama R, Morikawa N, Ushiyama R, Maruyama T, Sato R, Tsugane M, Takinoue M, Suzuki H.   +7 more
europepmc   +1 more source

Substrate‐Selective Temperature‐Controlled Synthesis of Thiophene Derivatives at Interfaces

Angewandte Chemie, EarlyView.
The deposition of a dithiophene derivative on Ag(111) at room temperature followed by annealing gives rise to molecular wires, whereas the adsorption of the same precursor on a hot substrate affords the formation of benzotrithiophene species. Abstract The temperature‐controlled transformation of organic molecules at interfaces is an incipient yet ...
Elena Pérez‐Elvira, Ana Barragán, Diego J. Vicent, Óscar Jóver, Aurelio Gallardo, Alba García‐Frutos, Lenka Černa, Koen Lauwaet, José Santos, Josefina Perles, José M. Gallego, Rodolfo Miranda, José I. Urgel, Jonas Björk, Marco Di Giovannantonio, Nazario Martín, David Écija   +16 more
wiley   +2 more sources

UXT oligomerization is essential for its role as an autophagy adaptor. [PDF]

iScience
Yoon MJ, Park J, Lee M, Ohk J, Choi TS, Choi EJ, Jung H, Kim C.   +7 more
europepmc   +1 more source

Insights into the Controlled Formation of Zr‐Based Metal–Organic Gels: Linking Macroscopic Properties with Molecular Information from Solution State NMR

Angewandte Chemie, EarlyView.
Real time STD/SDTD NMR unveils water structuring during UiO‐66 gelation under mild, acid‐free conditions compatible with biomolecule encapsulation. This approach bridges molecular‐scale solvent ordering with macroscopic gel properties, unlocking mechanistic insight for the rational design of MOF gels.
Juan C. Muñoz‐García, Francisco G. Moscoso, Elena M. Sánchez‐Fernández, Jenifer Santos, Jesús Angulo, Carolina Carrillo‐Carrión   +5 more
wiley   +2 more sources