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Purification of antisense oligonucleotides
2000Chromatography is an effective tool for obtaining high-purity synthetic oligonucleotides for a variety of end uses, including antisense drug therapy. Reversed-phase and anion-exchange chromatographies are widely used techniques for this application. While selectivity of these techniques can be modified by methods such as ion-pair RP-HPLC or affinity ...
Ranjit R. Deshmukh +2 more
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Therapeutic implications of antisense oligonucleotides
International Journal of Clinical & Laboratory Research, 1992Antisense oligonucleotides and their derivatives have been shown to be specific inhibitors of gene expression. They are considered a very promising new generation of drugs, potentially useful in most human diseases, including cancers and viral infections.
D. Lattuada +3 more
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ANTISENSE OLIGONUCLEOTIDES AS THERAPEUTIC AGENTS
Pharmacological Research, 1997The potential for modulating gene expression by the use of antisense oligonucleotides has become increasingly interesting in recent years. Antisense oligonucleotides are complementary nucleic acid fragments that hybridize to target sequences within RNA to form a DNA-RNA duplex, resulting in the block of translation of messenger RNA into the protein ...
ALAMA A +3 more
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Antisense oligonucleotides for therapeutic intervention
Current Biology, 1991Advances have been made in defining the best target sequences for use in antisense oligonucleotide technology, and new chemical derivatives of oligonucleotides are being investigated. Although the potential use of antisense oligonucleotide agents in the treatment of neoplastic, viral and parasitic diseases continues to be explored, they are not yet ...
Stephen L. Eck, Gary J. Nabel
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Structural modifications of antisense oligonucleotides
Il Farmaco, 2003Antisense oligonucleotides are efficient tools for the inhibition of gene expression in a sequence specific way. Natural oligonucleotides are decomposed rapidly in biological systems, which strongly restrict their application. In contrast, artificial oligonucleotides are designed to be more stable against degradation than the target mRNA, which results
Christian R. Noe, Ernst Urban
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Antisense oligonucleotide treatments for psoriasis
Expert Opinion on Biological Therapy, 2004Antisense oligonucleotides are emerging as an exciting therapeutic strategy for treating skin diseases such as psoriasis. Potential antisense targets are proteins upregulated in psoriatic skin, in particular those associated with inflammation (intercellular adhesion molecule [ICAM]-1, IL-2 and -8), proliferation (insulin-like growth factor type I ...
Christopher J. Wraight +2 more
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ChemInform Abstract: Chemistry of Antisense Oligonucleotides
ChemInform, 2000AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Lucius Kaufhold, Christian R. Noe
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Seminars in cancer biology, 1992
Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene ...
CALABRETTA, Bruno, Skorski T, Zon G.
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Antisense Anticancer Oligonucleotide Therapeutics
Current Cancer Drug Targets, 2001Recent progress made in molecular biology, biotechnology, and genetics, especially in identifying, cloning, sequencing and characterization of normal and pathogenic genes, has led to the development of genetic therapy. Major efforts in the field can be summarized in two general approaches: gene therapy and antisense therapy. The second is to deliver to
Gautam Prasad +3 more
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2006
Publisher Summary Antisense oligonucleotides (ASO) offer significant advantages over traditional methods in terms of specificity and versatility. ASOs validate the function of genes in vitro and in vivo. In addition, antisense oligonucleotides are developed as drugs with many products currently being tested in clinical trials. ASOs are short stretches
Erich Koller, Nicholas M. Dean
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Publisher Summary Antisense oligonucleotides (ASO) offer significant advantages over traditional methods in terms of specificity and versatility. ASOs validate the function of genes in vitro and in vivo. In addition, antisense oligonucleotides are developed as drugs with many products currently being tested in clinical trials. ASOs are short stretches
Erich Koller, Nicholas M. Dean
openaire +2 more sources