Results 291 to 300 of about 113,580 (306)
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Antisense and/or Immunostimulatory Oligonucleotide Therapeutics
Current Cancer Drug Targets, 2001Antisense technology, which is based on a simple and rational principle of Watson-Crick complementary base pairing of a short oligonucleotide with the targeted mRNA to downregulate the disease-causing gene product, has progressed tremendously in the last two decades.
Sudhir Agrawal, E R Kandimalla
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Conjugated Antisense Oligonucleotides
Nucleosides and Nucleotides, 1997Abstract We have employed chemical modification strategies to improve cellular ahsorption of oligonucleotides. These include the conjugation of various pendant moieties to the oligonucleotide to affect its overall physical properties such as hydrophobicity, charge, and amphipathicity as well as pendants that may mediate absorption by binding to certain
Isabelle Barber-Peoc'h +11 more
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The concept and application of antisense oligonucleotides
Diseases of the Colon & Rectum, 2001Since the identification of the double-stranded DNA helix by Watson and Crick in 1953, the knowledge of nucleotide structure and function has been an important potential tool in the study and therapy of disease. There is recent clinical evidence that antisense oligonucleotides may be important therapeutic compounds in the clinical therapy of a range of
Stanley T. Crooke, Bruce R. Yacyshyn
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Innovations in the Use of Antisense Oligonucleotides
Annals of the New York Academy of Sciences, 1990The use of antisense oligonucleotides for controlling genetic expression has recently received widespread attention, especially as a new class of potential chemotherapeutic agents. This coupled with the urgency of developing new effective therapies for acquired immunodeficiency syndrome (AIDS) has led to various antisense studies dealing with human ...
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Antisense oligonucleotide pharmacokinetics and metabolism
Expert Opinion on Drug Metabolism & Toxicology, 2009The use of oligonucleotides as therapeutic agents has elicited a great deal of interest. Basic understanding and evaluation of the pharmacokinetic properties of oligonucleotides is foundational to their appropriate design and application.To review the primary pharmacokinetic properties that drive successful use and delivery of oligonucleotides.The ...
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antisense oligonucleotides (AS-ODNs)
2009Class of new therapeutics planned for the treatment of viral infections, autoimmune disease, endocrine disease and cancers; AS-ODNs are small synthetic molecules of single-stranded DNA that suppress gene expression by binding to RNA templates in a sequence-specific manner, thus suppressing gene expression, mRNA translation and therefore the production ...
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Antisense Oligonucleotides as Antiviral Agentsa
Annals of the New York Academy of Sciences, 1992Alan D. B. Malcolm, Judy M. Coulson
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An Antisense Oligonucleotide Primer
Antisense and Nucleic Acid Drug Development, 1999openaire +3 more sources
Antisense oligonucleotide therapeutics
Expert Opinion on Investigational Drugs, 1999openaire +3 more sources