The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection [PDF]
Frontiers in Immunology, 2023 Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood.
Déborah Lécuyer +58 more
doaj +3 more sources
Migration study of phthalates from non-food plastic containers used in food preservation [PDF]
Heliyon, 2023 Phthalate acid esters (PAE) are used as additives in the formulation of plastics, to increase their flexibility and transparency. They can migrate from plastic packaging to food, then cause endocrine disruption in consumers. This migration depends on the
Olivier Songue Same +6 more
doaj +2 more sources
Olivier Deprez et les frontières de la bande dessinée
Relief: Revue Électronique de Littérature Francaise, 2008 La bande dessinée contemporaine est le résultat de trois révolutions : celle du contenu, qui n’est plus confiné à l’humour ; celle ensuite de son support, qui est devenu le livre ; celle enfin de ses techniques, qui ne se réduisent plus au dessin colorié.
Jan Baetens
doaj +6 more sources
Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes [PDF]
iScience, 2023 Summary: Metformin (MET) is the most prescribed antidiabetic drug, but its mechanisms of action remain elusive. Recent data point to the gut as MET’s primary target. Here, we explored the effect of MET on the gut glucose transport machinery.
Lorea Zubiaga +26 more
doaj +2 more sources
Inhibition of HIV-1 replication by primer RNA packaging inhibitors [PDF]
mBioAn essential step in the life cycle of human immunodeficiency virus type 1 (HIV-1) is the packaging of tRNA3Lys during viral assembly. This step, which requires the assembly of a ternary complex consisting of GagPol, mitochondrial lysyl-tRNA synthetase ...
Marc Mirande +4 more
doaj +2 more sources
The Role of Mesenchymal Stromal Cells in the Treatment of Bronchopulmonary Dysplasia: A Multi-Prong Approach for a Heterogeneous Disease. [PDF]
Compr PhysiolABSTRACT Acute lung injury can be a devastating ailment leading to death in patients of all ages. In preterm neonates, lung injury is unique and unlike what is seen in pediatric and adult populations. The physiology behind the acute lung injury endured in developing lungs and the chronicity of harmful stimuli vastly distinguish how bronchopulmonary ...
Deguise MO, Thébaud B.
europepmc +2 more sources
Different Pathways Leading to Integrase Inhibitors Resistance. [PDF]
Front Microbiol, 2016 Integrase strand-transfer inhibitors (INSTIs), such as raltegravir (RAL), elvitegravir, or dolutegravir (DTG), are efficient antiretroviral agents used in HIV treatment in order to inhibit retroviral integration.
Thierry E, Deprez E, Delelis O.
europepmc +2 more sources
High pressure jet injection of viscous solutions for endoscopic submucosal dissection (ESD): first clinical experience [PDF]
Endoscopy International Open, 2015 Background: Long lasting elevation is a key factor during endoscopic submucosal dissection (ESD) and can be obtained by water jet injection of saline solution or by viscous macromolecular solutions. In a previous animal study, we assessed the Nestis Enki
Mathieu Pioche +13 more
doaj +2 more sources
Twenty-year trends in patient referrals throughout the creation and development of a regional memory clinic network. [PDF]
Alzheimers Dement (N Y), 2020 Abstract Introduction Memory clinics (MCs) are the main model for dementia diagnosis and care. Following the development of a MC network in Northern France, our objectives were to assess its impact on patient characteristics over 20 years. Methods The characteristics of new consultants were studied from 1997 to 2016.
Chen Y +9 more
europepmc +2 more sources
CDC20B is required for deuterosome-mediated centriole production in multiciliated cells [PDF]
Nature Communications, 2018 In vertebrate multiciliated cells, most centrioles are synthesized and released by poorly characterized structures called deuterosomes. Here, the authors report that the previously-uncharacterized Cdc20b in mouse and Xenopus associates with deuterosomes ...
Diego R. Revinski +14 more
doaj +2 more sources